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Lei Xi
Researcher at University of California, San Diego
Publications - 4
Citations - 213
Lei Xi is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Cell. The author has an hindex of 1, co-authored 1 publications receiving 158 citations.
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Journal ArticleDOI
WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis
Hong Ouyang,Yuanchao Xue,Ying Lin,Xiaohui Zhang,Lei Xi,Sherrina Patel,Huimin Cai,Jing Luo,Meixia Zhang,Ming Zhang,Yang Yang,Gen Li,Hairi Li,Wei Jiang,Emily Yeh,Jonathan H. Lin,Michelle Pei,Jin Zhu,Guiqun Cao,Liangfang Zhang,Benjamin D. Yu,Shaochen Chen,Xiang-Dong Fu,Yizhi Liu,Kang Zhang +24 more
TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.
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The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells
TL;DR: In this article , a pan-cancer type analysis was performed, which revealed enhanced 6 mA metabolism in diverse cancer types, and the study was then focused on the regulation of 6mA metabolism, as well as its effects on TSCC cells.
Journal ArticleDOI
The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells
TL;DR: In this paper , a pan-cancer type analysis was performed, which revealed enhanced 6 mA metabolism in diverse cancer types, and the study was then focused on the regulation of 6mA metabolism, as well as its effects on TSCC cells.
Journal ArticleDOI
Pigment Epithelium-Derived Factor Protects Retinal Neural Cells and Prevents Pathological Angiogenesis in an Ex Vivo Ischemia Model
Lei Xi,Marina Tikhonovich,Antje Biesemeier,Sylvie Julien-Schraermeyer,Ulrich Schraermeyer,Alexander Tschulakow +5 more
TL;DR: A new whole organ culture model for ischemia/hypoxia in rat eyes and the effects of pigment epithelium derived factor (PEDF) protein on the eye tissues highlighted the potential of PEDF as a promising candidate for treating wet AMD.