Meixia Zhang

TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.

TL;DR: It is suggested that the preservation of visual acuity was likely achieved through host photoreceptor rescue, and hRPC transplantation into the subretinal space of RCS rats was well tolerated, with no adverse effects such as tumor formation noted at 12 weeks after treatment.

TL;DR: In this paper, deep learning models were used to identify chronic kidney disease and type 2 diabetes from fundus images or in combination with clinical metadata (age, sex, height, weight, body mass index and blood pressure) with areas under the receiver operating characteristic curve of 0.85-0.93.

TL;DR: Loss of PAX6 converts LSCs to epidermal stem cells, as demonstrated by a switch in the keratin gene expression profile and by the appearance of congenital dermoid tissue.

TL;DR: It is demonstrated that mouse Müller glia cells have the capacity to be reprogrammed into the retinal neuronal cell fate and are competent to give rise to photoreceptors under a defined culture condition and the feasibility of using Müllers glia as a potential source for retinal repair and regeneration is demonstrated.