E
Emily Yeh
Researcher at University of California, San Diego
Publications - 5
Citations - 663
Emily Yeh is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stem cell & Eye development. The author has an hindex of 5, co-authored 5 publications receiving 519 citations.
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Journal ArticleDOI
Lanosterol reverses protein aggregation in cataracts
Ling Zhao,Xiang-Jun Chen,Jie Zhu,Yi-Bo Xi,Xu Yang,Li-Dan Hu,Hong Ouyang,Sherrina Patel,Xin Jin,Danni Lin,Frances Wu,Ken Flagg,Huimin Cai,Gen Li,Guiqun Cao,Ying Lin,Daniel Chen,Cindy Wen,Christopher Chung,Yandong Wang,Austin Qiu,Emily Yeh,Wenqiu Wang,Xun Hu,Seanna Grob,Ruben Abagyan,Zhiguang Su,Harry C. Tjondro,Xi-Juan Zhao,Hongrong Luo,Rui Hou,J. Jefferson,P. Perry,Weiwei Gao,Igor Kozak,David B. Granet,Yingrui Li,Xiaodong Sun,Jun Wang,Liangfang Zhang,Yizhi Liu,Yong-Bin Yan,Kang Zhang +42 more
TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.
Journal ArticleDOI
WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis
Hong Ouyang,Yuanchao Xue,Ying Lin,Xiaohui Zhang,Lei Xi,Sherrina Patel,Huimin Cai,Jing Luo,Meixia Zhang,Ming Zhang,Yang Yang,Gen Li,Hairi Li,Wei Jiang,Emily Yeh,Jonathan H. Lin,Michelle Pei,Jin Zhu,Guiqun Cao,Liangfang Zhang,Benjamin D. Yu,Shaochen Chen,Xiang-Dong Fu,Yizhi Liu,Kang Zhang +24 more
TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.
Journal ArticleDOI
P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
Dorota Skowronska-Krawczyk,Ling Zhao,Ling Zhao,Jie Zhu,Jie Zhu,Robert N. Weinreb,Guiqun Cao,Jing Luo,Ken Flagg,Sherrina Patel,Cindy Wen,Martin Krupa,Hongrong Luo,Hong Ouyang,Hong Ouyang,Danni Lin,Wenqiu Wang,Wenqiu Wang,Gen Li,Yanxin Xu,Oulan Li,Christopher Chung,Emily Yeh,Maryam Jafari,Michael Ai,Zheng Zhong,William Shi,Lianghong Zheng,Michal Krawczyk,Daniel Chen,Catherine Shi,Carolyn Zin,Jin Zhu,Pamela L. Mellon,Weiwei Gao,Ruben Abagyan,Liangfang Zhang,Xiaodong Sun,Sheng Zhong,Yehong Zhuo,Michael G. Rosenfeld,Yizhi Liu,Kang Zhang +42 more
TL;DR: It is demonstrated that the genetic effect of the SIX6 risk variant is enhanced by another major POAG risk gene, p16INK4a, which leads to RGC senescence in adult human retinas, providing a unified theory of glaucoma pathogenesis.
Journal ArticleDOI
Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease
Gen Li,Fan Xu,Jie Zhu,Michal Krawczyk,Ying Zhang,Jin Yuan,Sherrinal Patel,Yujuan Wang,Ying Lin,Ming Zhang,Huimin Cai,Daniel Chen,Meixia Zhang,Guiqun Cao,Guiqun Cao,Emily Yeh,Danni Lin,Qiao Su,Wenwen Li,George L. Sen,Natalie A. Afshari,Shaochen Chen,Richard L. Maas,Xiang-Dong Fu,Kang Zhang,Yizhi Liu,Hong Ouyang +26 more
TL;DR: Loss of PAX6 converts LSCs to epidermal stem cells, as demonstrated by a switch in the keratin gene expression profile and by the appearance of congenital dermoid tissue.
Journal ArticleDOI
Corrigendum: Lanosterol reverses protein aggregation in cataracts
Ling Zhao,Xiang-Jun Chen,Jie Zhu,Yi-Bo Xi,Xu Yang,Li-Dan Hu,Hong Ouyang,Sherrina Patel,Xin Jin,Danni Lin,Frances Wu,Ken Flagg,Huimin Cai,Gen Li,Guiqun Cao,Ying Lin,Daniel Chen,Cindy Wen,Christopher Chung,Yandong Wang,Austin Qiu,Emily Yeh,Wenqiu Wang,Xun Hu,Seanna Grob,Ruben Abagyan,Zhiguang Su,Harry C. Tjondro,Xi-Juan Zhao,Hongrong Luo,Rui Hou,John Perry,Weiwei Gao,Igor Kozak,David B. Granet,Yingrui Li,Xiaodong Sun,Jun Wang,Liangfang Zhang,Yizhi Liu,Yong-Bin Yan,Kang Zhang +41 more
TL;DR: This corrects the article to show that the H2O2/H2O/O2 balance is determined by a combination of H2A and O2 values, not necessarily reflecting a direct relationship between these numbers and each other.