J
Jing Luo
Researcher at University of California, San Diego
Publications - 36
Citations - 1237
Jing Luo is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 22 publications receiving 1023 citations. Previous affiliations of Jing Luo include Central South University & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP
Fa-Xing Yu,Jing Luo,Jung-Soon Mo,Guangbo Liu,Young Chul Kim,Zhipeng Meng,Ling Zhao,Gholam A. Peyman,Hong Ouyang,Wei Jiang,Jiagang Zhao,Xu Chen,Liangfang Zhang,Cun-Yu Wang,Boris C. Bastian,Kang Zhang,Kun-Liang Guan +16 more
TL;DR: An essential role of the Hippo-YAP pathway in Gq/11-induced tumorigenesis is revealed and YAP is suggested as a potential drug target for UM patients carrying mutations in GNAQ or GNA11.
Journal ArticleDOI
WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis
Hong Ouyang,Yuanchao Xue,Ying Lin,Xiaohui Zhang,Lei Xi,Sherrina Patel,Huimin Cai,Jing Luo,Meixia Zhang,Ming Zhang,Yang Yang,Gen Li,Hairi Li,Wei Jiang,Emily Yeh,Jonathan H. Lin,Michelle Pei,Jin Zhu,Guiqun Cao,Liangfang Zhang,Benjamin D. Yu,Shaochen Chen,Xiang-Dong Fu,Yizhi Liu,Kang Zhang +24 more
TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.
Journal ArticleDOI
Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids
Peter X. Shaw,Li Zhang,Ming Zhang,Hongjun Du,Hongjun Du,Ling Zhao,Ling Zhao,Clara Lee,Seanna Grob,Siok Lam Lim,Guy Hughes,Janet Lee,Matthew Bedell,Mark H. Nelson,Fang Lu,Martin Krupa,Jing Luo,Hong Ouyang,Zhidan Tu,Zhiguang Su,Jin Zhu,Jin Zhu,Xinran Wei,Xinran Wei,Zishan Feng,Yaou Duan,Yaou Duan,Zhenglin Yang,Henry Ferreyra,Dirk-Uwe Bartsch,Igor Kozak,Liangfang Zhang,Feng Lin,Hui Sun,Hong Feng,Kang Zhang,Kang Zhang +36 more
TL;DR: It is demonstrated that CFH binds to oxPLs and that oxPL stimulation increases expression of genes involved in macrophage infiltration, inflammation, and neovascularization in the eye.
Journal ArticleDOI
Human Retinal Progenitor Cell Transplantation Preserves Vision
Jing Luo,Jing Luo,Petr Baranov,Sherrina Patel,Hong Ouyang,John Quach,Frances Wu,Austin Qiu,Hongrong Luo,Caroline A Hicks,Jing Zeng,Jing Zeng,Jing Zhu,Jessica Lu,Nicole Sfeir,Cindy Wen,Meixia Zhang,Victoria Reade,Sara Patel,John Sinden,Xiaodong Sun,Peter X. Shaw,Michael J. Young,Kang Zhang +23 more
TL;DR: It is suggested that the preservation of visual acuity was likely achieved through host photoreceptor rescue, and hRPC transplantation into the subretinal space of RCS rats was well tolerated, with no adverse effects such as tumor formation noted at 12 weeks after treatment.
Journal ArticleDOI
Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye
Viet Anh Nguyen Huu,Jing Luo,Jie Zhu,Jing Zhu,Sherrina Patel,Alexander Boone,Enas Mahmoud,Cathryn L. McFearin,Jason Olejniczak,Caroline de Gracia Lux,Jacques Lux,Nadezda Fomina,Michelle Huynh,Kang Zhang,Adah Almutairi +14 more
TL;DR: A novel nanoparticle depot platform for on-demand drug delivery using a far ultraviolet (UV) light-degradable polymer, which allows noninvasively triggered drug release using brief, low-power light exposure.