L
Leila Gogsadze
Researcher at National Institutes of Health
Publications - 9
Citations - 716
Leila Gogsadze is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rhinovirus & Cytokine. The author has an hindex of 6, co-authored 9 publications receiving 588 citations.
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Journal ArticleDOI
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
David A. Jackson,David A. Jackson,Heidi Makrinioti,Batika M. J. Rana,Betty Shamji,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Joseph Footitt,Joseph Footitt,Jerico del-Rosario,Jerico del-Rosario,Aurica G. Telcian,A A Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,Jaideep Dhariwal,James D. Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A. Stanciu,Musa Khaitov,Nathan W. Bartlett,Michael R. Edwards,Onn Min Kon,Patrick Mallia,Patrick Mallia,Nikolaos G. Papadopoulos,Cezmi A. Akdis,John Westwick,Matthew J. Edwards,David J. Cousins,Ross P. Walton,Sebastian L. Johnston,Sebastian L. Johnston +38 more
TL;DR: IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Journal ArticleDOI
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
Trevor T. Hansel,Tanushree Tunstall,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Betty Shamji,Ajerico del-Rosario,Ajerico del-Rosario,Jaideep Dhariwal,Jaideep Dhariwal,Paul D. W. Kirk,Michael P. H. Stumpf,Jens Koopmann,Jens Koopmann,Aurica G. Telcian,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Luminita A. Stanciu,Nathan W. Bartlett,Michael R. Edwards,Ross P. Walton,Patrick Mallia,Patrick Mallia,Toby Hunt,Trevor Hunt,Duncan Hunt,John Westwick,Matthew J. Edwards,Onn Min Kon,David A. Jackson,Sebastian L. Johnston,Sebastian L. Johnston +31 more
TL;DR: Precision sampling of mucosal lining fluid identifies robust interferon and type 2 responses in the upper and lower airways of asthmatics during an asthma exacerbation.
Journal ArticleDOI
An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation
Stephanie Traub,A A Nikonova,Alan M. Carruthers,Rebecca Dunmore,Katherine A. Vousden,Leila Gogsadze,Weidong Hao,Qing Zhu,Katie Bernard,Jie Zhu,Michael Dymond,Gary R. McLean,Ross P. Walton,Nicholas Glanville,Alison A. Humbles,Musa Khaitov,Ted Wells,Roland Kolbeck,Andrew Leishman,Matthew A. Sleeman,Nathan W. Bartlett,Sebastian L. Johnston +21 more
TL;DR: A human ICAM-1 domain-1-specific antibody can prevent major group HRV entry and induction of airway inflammation in vivo, and reduce cellular inflammation, pro-inflammatory cytokine induction and virus load in vivo.
Journal ArticleDOI
Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1.
Gary R. McLean,Ross P. Walton,Shweta Shetty,Tamlyn Peel,Nasren Paktiawal,Tatiana Kebadze,Leila Gogsadze,Katarzyna Niespodziana,Rudolf Valenta,Nathan W. Bartlett,Sebastian L. Johnston +10 more
TL;DR: It is concluded that VP1 based antigens combined with adjuvants may permit successful antibody-mediated vaccine design and development.
Journal ArticleDOI
Pathogen Sensing Pathways in Human Embryonic Stem Cell Derived-Endothelial Cells: Role of NOD1 Receptors
Daniel M. Reed,Gabor Foldes,Timothy Gatheral,Koralia E. Paschalaki,Zsuzsanna Lendvai,Zsolt Bagyura,Tamás Németh,Judit Skopál,Béla Merkely,Aurica G. Telcian,Leila Gogsadze,Michael R. Edwards,Peter J. Gough,John Bertin,Sebastian L. Johnston,Sian E. Harding,Jane A. Mitchell +16 more
TL;DR: Compared TLR4 and NOD1 responses in hESC-EC with those of endothelial cells derived from other stem cells and with human umbilical vein endothelial Cells (HUVEC), this data suggests that hESc-EC may be protected from unwantedTLR4-mediated vascular inflammation, thus offering a potential therapeutic advantage.