L
Leondios G. Kostrikis
Researcher at University of Cyprus
Publications - 86
Citations - 7580
Leondios G. Kostrikis is an academic researcher from University of Cyprus. The author has contributed to research in topics: Population & Genotype. The author has an hindex of 39, co-authored 82 publications receiving 7154 citations. Previous affiliations of Leondios G. Kostrikis include Aaron Diamond AIDS Research Center & National and Kapodistrian University of Athens.
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Journal ArticleDOI
Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
Xia Jin,Daniel E. Bauer,Sarah Tuttleton,Sharon R Lewin,Agegnehu Gettie,James Blanchard,Craig E. Irwin,Jeffrey T. Safrit,John E. Mittler,Leor S. Weinberger,Leondios G. Kostrikis,Linqi Zhang,Alan S. Perelson,David D. Ho +13 more
TL;DR: It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.
Journal ArticleDOI
Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy.
Mark Sharkey,Ian Teo,Thomas C. Greenough,Natalia Sharova,Katherine Luzuriaga,John L. Sullivan,R. Pat Bucy,Leondios G. Kostrikis,Ashley T. Haase,Claire Veryard,Raul Davaro,Sarah H. Cheeseman,Jennifer S. Daly,Carol A. Bova,Richard T. Ellison,Brian J. Mady,Kwan Kew Lai,Graeme Moyle,Mark T. Nelson,Brian Gazzard,Sunil Shaunak,Mario Stevenson +21 more
TL;DR: It is demonstrated here ongoing virus replication in a large percentage of infected individuals on highly active anti-retroviral therapy, despite sustained undetectable levels of plasma viral RNA, has important implications for the clinical management of HIV-1-infected individuals and for the development of virus eradication strategies.
Journal ArticleDOI
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.
Leondios G. Kostrikis,Yaoxing Huang,John P. Moore,Steve M. Wolinsky,Linqi Zhang,Yong Guo,Lisa Deutsch,John P. Phair,Avidan U. Neumann,David D. Ho +9 more
TL;DR: CCR2-V64I is indeed protective against disease progression and is shown to be in complete linkage disequilibrium with a point mutation in the CCR5 regulatory region.
Journal ArticleDOI
Spectral Genotyping of Human Alleles
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Journal ArticleDOI
Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy.
Linqi Zhang,Sharon R Lewin,Martin Markowitz,Hsi-Hsun Lin,Eva Skulsky,Rose Karanicolas,Yuxian He,Xia Jin,Sarah Tuttleton,Mika Vesanen,Hans M. L. Spiegel,Rhonda G. Kost,Jan van Lunzen,Hans-Juergen Stellbrink,Steven M. Wolinsky,William Borkowsky,Paul Palumbo,Leondios G. Kostrikis,David D. Ho +18 more
TL;DR: Overall, it is difficult to invoke thymic regenerative failure as a generalized mechanism for CD4 lymphocyte depletion in HIV-1 infection, as α1 circle numbers are normal in a substantial subset of HIV–1–infected individuals.