Brandon S. Razooky

TL;DR: The COVID Human Genetic Effort established to test the general hypothesis that life-threatening COVID-19 in some or most patients may be caused by monogenic inborn errors of immunity to SARS-CoV-2 with incomplete or complete penetrance finds an enrichment in variants predicted to be loss-of-function (pLOF), with a minor allele frequency <0.001.

TL;DR: Time-lapse fluorescence microscopy is used to analyze 8,000 individual human genomic loci and finds that at virtually all loci, episodic bursting—as opposed to constitutive expression—is the predominant mode of expression.

TL;DR: In this paper, the authors quantified expression noise from the long terminal repeat (LTR) promoter at different HIV-1 integration sites across the human genome and found that the measured noise levels are inconsistent with constitutive gene expression models, and that each burst generates an average of 2-10 mRNA transcripts before the promoter returned to an inactive state.

TL;DR: Synthetically decouple viral dependence on cellular environment from viral transcription and show that Tat feedback is sufficient to regulate latency independent of cellular activation, demonstrating that a largely autonomous, viral-encoded program underlies HIV latency.

TL;DR: It is proposed that TMEM41B is recruited to flavivirus RNA replication complexes to facilitate membrane curvature, which creates a protected environment for viral genome replication.