L
Leqian Yu
Researcher at University of Texas Southwestern Medical Center
Publications - 32
Citations - 938
Leqian Yu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 11, co-authored 22 publications receiving 511 citations. Previous affiliations of Leqian Yu include Kyoto University.
Papers
More filters
Journal ArticleDOI
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells
Yanxiao Zhang,Ting Li,Sebastian Preissl,Sebastian Preissl,Maria Luisa Amaral,Jonathan D. Grinstein,Elie Farah,Eugin Destici,Yunjiang Qiu,Yunjiang Qiu,Rong Hu,Ah Young Lee,Sora Chee,Kaiyue Ma,Zhen Ye,Quan Zhu,Hui Huang,Hui Huang,Rongxin Fang,Rongxin Fang,Leqian Yu,Juan Carlos Izpisua Belmonte,Jun Wu,Sylvia M. Evans,Sylvia M. Evans,Neil C. Chi,Bing Ren +26 more
TL;DR: A role for the primate-specific endogenous retrotransposon human endogenous retrovirus subfamily H (HERV-H) in creating topologically associating domains (TADs) in hPSCs is discovered by interrogating chromatin reorganization during human pluripotent stem cell (hPSC) differentiation.
Journal ArticleDOI
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Ronghui Li,Cuiqing Zhong,Yang Yu,Yang Yu,Haisong Liu,Masahiro Sakurai,Masahiro Sakurai,Leqian Yu,Min Zheying,Lei Shi,Lei Shi,Yulei Wei,Yulei Wei,Yuta Takahashi,Hsin Kai Liao,Hsin Kai Liao,Jie Qiao,Hongkui Deng,Estrella Núñez-Delicado,Concepcion Rodriguez Esteban,Jun Wu,Juan Carlos Izpisua Belmonte +21 more
TL;DR: EPS-blastoids provide a unique platform for studying early embryogenesis and pave the way to creating viable synthetic embryos by using cultured cells through lineage segregation and self-organization.
Journal ArticleDOI
Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium
Junjun Li,Itsunari Minami,Motoko Shiozaki,Leqian Yu,Shin Yajima,Shigeru Miyagawa,Yuji Shiba,Nobuhiro Morone,Satsuki Fukushima,Momoko Yoshioka,Sisi Li,Jing Qiao,X. Li,Lin Wang,Hidetoshi Kotera,Norio Nakatsuji,Yoshiki Sawa,Yong Chen,Yong Chen,Li Liu +19 more
TL;DR: A handy framework for cardiac tissue engineering is established by cultivating hiPSC-CMs on low-thickness aligned nanofibers made of biodegradable poly(D,L-lactic-co-glycolic acid) polymer, resulting in upregulated cardiac biomarkers and enhanced cardiac functions.
Journal ArticleDOI
Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification
Leqian Yu,Yulei Wei,Yulei Wei,Hai Xi Sun,Ahmed K. Mahdi,Carlos A. Pinzon Arteaga,Masahiro Sakurai,Daniel A. Schmitz,Canbin Zheng,Canbin Zheng,Emily D. Ballard,Jie Li,Noriko Tanaka,Aoi Kohara,Daiji Okamura,A. Mutto,Ying Gu,Pablo J. Ross,Jun Wu +18 more
TL;DR: By modulating fibroblast growth factor (FGF), transforming growth factor β (TGF-β), and WNT pathways, PSCs are derived from mice, horses, and humans (designated as XPSCs) that are permissive for direct PGC-like cell induction in vitro and are capable of contributing to intra- or inter-species chimeras in vivo.
Journal ArticleDOI
Induction and differentiation of human induced pluripotent stem cells into functional cardiomyocytes on a compartmented monolayer of gelatin nanofibers.
TL;DR: A patch method by electrospinning and crosslinking of monolayer gelatin nanofibers on a honeycomb frame made of poly(ethylene glycol) diacrylate (PEGDA) has been developed, leading to a uniform cardiac layer with homogeneous contraction.