L
Lígia C. Gomes-da-Silva
Researcher at University of Coimbra
Publications - 37
Citations - 1231
Lígia C. Gomes-da-Silva is an academic researcher from University of Coimbra. The author has contributed to research in topics: Photodynamic therapy & Medicine. The author has an hindex of 15, co-authored 28 publications receiving 785 citations. Previous affiliations of Lígia C. Gomes-da-Silva include French Institute of Health and Medical Research & Jagiellonian University.
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Journal ArticleDOI
Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity.
TL;DR: The investigation of the mechanisms of cell death under the oxidative stress of PDT is of paramount importance to understand how the immune system is activated and, ultimately, to make PDT a more appealing/relevant therapeutic option.
Journal ArticleDOI
Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges.
Lígia C. Gomes-da-Silva,Nuno A. Fonseca,Vera Moura,Maria C. Pedroso de Lima,Sérgio Simões,João Nuno Moreira +5 more
TL;DR: The design and synthesis of novel cationic lipids that are more fusogenic and the use of internalizing targeting ligands have contributed to the emergence of novel lipid-based nanoparticles with remarkable transfection efficiency.
Journal ArticleDOI
eIF2α phosphorylation is pathognomonic for immunogenic cell death.
Lucillia Bezu,Allan Sauvat,Juliette Humeau,Lígia C. Gomes-da-Silva,Kristina Iribarren,Sabrina Forveille,Pauline Garcia,Liwei Zhao,Peng Liu,Laurence Zitvogel,Laurence Zitvogel,Laura Senovilla,Oliver Kepp,Guido Kroemer +13 more
TL;DR: Machine-learning approaches were used to determine the physicochemical properties of drugs that induce ICD, revealing that the sole ER stress response relevant to the algorithm is eIF2α phosphorylation with its downstream consequences CALR exposure, stress granule formation and autophagy induction.
Journal ArticleDOI
Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus
Lígia C. Gomes-da-Silva,Liwei Zhao,Liwei Zhao,Liwei Zhao,Lucillia Bezu,Lucillia Bezu,Lucillia Bezu,Heng Zhou,Heng Zhou,Heng Zhou,Allan Sauvat,Allan Sauvat,Allan Sauvat,Peng Liu,Peng Liu,Peng Liu,Sylvère Durand,Sylvère Durand,Marion Leduc,Marion Leduc,Marion Leduc,Sylvie Souquere,Sylvie Souquere,Friedemann Loos,Friedemann Loos,Friedemann Loos,Laura Mondragón,Laura Mondragón,Laura Mondragón,Baldur Sveinbjørnsson,Øystein Rekdal,Gaelle Boncompain,Franck Perez,Luis G. Arnaut,Oliver Kepp,Oliver Kepp,Oliver Kepp,Guido Kroemer +37 more
TL;DR: Results point to the capacity of redaporfin to kill tumor cells via destroying ER/GA function through the inhibition of protein secretion by PDT‐treated cancer cells.
Journal ArticleDOI
Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination.
Nuno A. Fonseca,Ana Sofia Rodrigues,Paulo Rodrigues-Santos,Vera Alves,Ana C. Gregório,Ângela Valério-Fernandes,Lígia C. Gomes-da-Silva,Manuel Santos Rosa,Vera Moura,João Ramalho-Santos,Sérgio Simões,João Nuno Moreira +11 more
TL;DR: Questions on whether nucleolin was a common receptor among breast CSC and non-SCC and whether it could be exploited for targeting purposes are addressed and nucleolin-specific therapeutic tools capable of simultaneous debulk multiple cellular compartments of the tumor microenvironment may pave the way towards a specific treatment for TNBC patient care.