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Liwei Zhao
Researcher at Institut Gustave Roussy
Publications - 40
Citations - 1304
Liwei Zhao is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Immunogenic cell death & Medicine. The author has an hindex of 11, co-authored 31 publications receiving 524 citations. Previous affiliations of Liwei Zhao include Institut Universitaire de France & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Detection of immunogenic cell death and its relevance for cancer therapy
Jitka Fucikova,Oliver Kepp,Lenka Kasikova,Giulia Petroni,Takahiro Yamazaki,Peng Liu,Liwei Zhao,Radek Spisek,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi +10 more
TL;DR: Qualitative approaches for measuring ICD markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer are outlined.
Journal ArticleDOI
Crizotinib-induced immunogenic cell death in non-small cell lung cancer
Peng Liu,Liwei Zhao,Jonathan Pol,Sarah Levesque,Adriana Petrazzuolo,Christina Pfirschke,Camilla Engblom,Steffen Rickelt,Takahiro Yamazaki,Kristina Iribarren,Laura Senovilla,Lucillia Bezu,Erika Vacchelli,Valentina Sica,Andréa Melis,Tiffany Martin,Lin Xia,Heng Yang,Qingqing Li,Jinfeng Chen,Sylvère Durand,Fanny Aprahamian,Deborah Lefevre,Sophie Broutin,Angelo Paci,Angelo Paci,Amaury Bongers,Veronique Minard-Colin,Eric Tartour,Laurence Zitvogel,Lionel Apetoh,Yuting Ma,Mikael J. Pittet,Oliver Kepp,Guido Kroemer +34 more
TL;DR: It is shown that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade and can exert their anticancer effect through indirect immune-dependent mechanism.
Journal ArticleDOI
eIF2α phosphorylation is pathognomonic for immunogenic cell death.
Lucillia Bezu,Allan Sauvat,Juliette Humeau,Lígia C. Gomes-da-Silva,Kristina Iribarren,Sabrina Forveille,Pauline Garcia,Liwei Zhao,Peng Liu,Laurence Zitvogel,Laurence Zitvogel,Laura Senovilla,Oliver Kepp,Guido Kroemer +13 more
TL;DR: Machine-learning approaches were used to determine the physicochemical properties of drugs that induce ICD, revealing that the sole ER stress response relevant to the algorithm is eIF2α phosphorylation with its downstream consequences CALR exposure, stress granule formation and autophagy induction.
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Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade
Gladys Ferrere,Maryam Tidjani Alou,Peng Liu,Anne-Gaëlle Goubet,Marine Fidelle,Oliver Kepp,Sylvère Durand,Valerio Iebba,Aurélie Fluckiger,Romain Daillère,Cassandra Thelemaque,Claudia Grajeda-Iglesias,Carolina Alves Costa Silva,Fanny Aprahamian,Deborah Lefevre,Liwei Zhao,Bernhard Ryffel,Emeline Colomba,Monica Arnedos,Damien Drubay,Conrad Rauber,Didier Raoult,Francesco Asnicar,Tim D. Spector,Nicola Segata,Lisa Derosa,Guido Kroemer,Laurence Zitvogel +27 more
TL;DR: It is demonstrated that ketogenic diet induces a 3HB-mediated antineoplastic effect that relies on T cell–mediated cancer immunosurveillance.
Journal ArticleDOI
Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus
Lígia C. Gomes-da-Silva,Liwei Zhao,Liwei Zhao,Liwei Zhao,Lucillia Bezu,Lucillia Bezu,Lucillia Bezu,Heng Zhou,Heng Zhou,Heng Zhou,Allan Sauvat,Allan Sauvat,Allan Sauvat,Peng Liu,Peng Liu,Peng Liu,Sylvère Durand,Sylvère Durand,Marion Leduc,Marion Leduc,Marion Leduc,Sylvie Souquere,Sylvie Souquere,Friedemann Loos,Friedemann Loos,Friedemann Loos,Laura Mondragón,Laura Mondragón,Laura Mondragón,Baldur Sveinbjørnsson,Øystein Rekdal,Gaelle Boncompain,Franck Perez,Luis G. Arnaut,Oliver Kepp,Oliver Kepp,Oliver Kepp,Guido Kroemer +37 more
TL;DR: Results point to the capacity of redaporfin to kill tumor cells via destroying ER/GA function through the inhibition of protein secretion by PDT‐treated cancer cells.