Lothar Rink

TL;DR: There were several effects on the cellular composition of adaptive immunity, affecting both T- and B-cells, however, the values were not generally outside the reference ranges for healthy adult individuals and did not indicate overt functional immunodeficiency, even in subjects with the uppermost PCB burden.

TL;DR: It is demonstrated that calcium mobilization is an isotype‐independent event that triggers the dephosphorylation of NFAT, and it is shown that BCR activation followed by MHC‐II ligation increases the activation ofNFAT.

TL;DR: These findings support the ideas that the induced MHC II complex is completely functional and that neutrophils may be able to present antigens, and clearly demonstrate that after induction of M HC II, neutrophil are able to respond to MHC I‐specific stimulation.

TL;DR: Depletion of CNS 5-HT via dietary TRP depletion appears to have no statistically significant short-term impact on cytokine concentrations in healthy adults, and future research on immunological stressors in combination with challenge techniques will be of value in order to further disentangle the complex interplay between brain 5- HT synthesis and immunological pathways.

TL;DR: Investigation of MAS-specific cytokine induction in humans and mice found an overproduction of proinflammatory cytokines and a significantly decreased capacity to induce the anti-inflammatory cytokine IL-10 and IL-1RA, which may explain an MHC linkage.