L
Lothar Rink
Researcher at RWTH Aachen University
Publications - 254
Citations - 15719
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications receiving 13189 citations. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration.
Eva Rosenkranz,Martina Maywald,Ralf-Dieter Hilgers,Anne Brieger,Tim Clarner,Markus Kipp,Markus Kipp,Birgit Plümäkers,Sören Meyer,Tanja Schwerdtle,Lothar Rink +10 more
TL;DR: Cumulatively, zinc supplementation seems to be capable to induce tolerance in unwanted immune reactions by increasing iTreg cells, which makes zinc a promising future tool for treating autoimmune diseases without suppressing the immune system.
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Chelation of Free Zn2+ Impairs Chemotaxis, Phagocytosis, Oxidative Burst, Degranulation, and Cytokine Production by Neutrophil Granulocytes
TL;DR: Free intracellular Zn2+ plays essential roles in multiple neutrophil functions, affecting extravasation to the site of the infection, uptake and killing of microorganisms, and inflammation.
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Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response.
TL;DR: In in vitro experiments, it is shown that zinc maintains the antigenic potency of the host while blocking the allogeneic response, which is the first step towards a new generation of immunosuppressants.
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Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.
Eva Rosenkranz,Ralf-Dieter Hilgers,Peter Uciechowski,Arnd Petersen,Birgit Plümäkers,Lothar Rink +5 more
TL;DR: Zinc may regulate unwanted hyperresponsive immune reactions by suppressing proliferation through a significant shift from IL-10 to the Th1 cytokine IFN-γ, and enhanced regulatory T cell numbers, without negatively affecting the immune system.
Journal Article
Zinc enhances lipopolysaccharide-induced monokine secretion by alteration of fluidity state of lipopolysaccharide.
Nele Wellinghausen,Andra B. Schromm,Ulrich Seydel,Klaus Brandenburg,Jürgen Luhm,Holger Kirchner,Lothar Rink +6 more
TL;DR: The data indicate that the zinc level represents a relevant clinical parameter in the treatment of Gram-negative infection, and reveals potential risks in the therapeutic application of zinc.