L
Lothar Rink
Researcher at RWTH Aachen University
Publications - 254
Citations - 15719
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications receiving 13189 citations. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Journal ArticleDOI
β-(1→3)-D-glucan modulates DNA binding of nuclear factors κB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1β/IL-1 receptor antagonist ratio
Juergen Luhm,Ulrich Langenkamp,Jenny Hensel,Christoph Frohn,Joerg M Brand,Holger Hennig,Lothar Rink,Petra Koritke,Nadine Wittkopf,David L. Williams,Antje Mueller +10 more
TL;DR: β-1→3-D-glucans may induce beneficial effects in the presence of pro-inflammatory responses, downstream of receptor binding and signaling by switching a pro- to an anti-inflammatory IL-1RA-mediated reaction.
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Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes.
TL;DR: Experiments in the T lymphocyte cell line Jurkat and primary human lymphocytes show that TMS and its active metabolite, ethyl mercury, cause an increase in signal intensity with probes designed for the detection of either calcium or zinc ions.
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A new closed-tube multiplex real-time PCR to detect eleven superantigens of Streptococcus pyogenes identifies a strain without superantigen activity
Maria Lintges,Sabine Arlt,Peter Uciechowski,Birgit Plümäkers,Ralf René Reinert,Adnan Al-Lahham,Rudolf Lütticken,Lothar Rink +7 more
TL;DR: One strain without any SAg gene is identified, which contrasts with previous reports describing SAg genes located on every Streptococcus pyogenes genome and is hypothesized that clinical isolates from patients may overrepresent bacterial strains with pathogenic factors, such as SAgs.
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Zinc supplementation plays a crucial role in T helper 9 differentiation in allogeneic immune reactions and non-activated T cells.
TL;DR: Zinc supplementation can be considered as useful additive to dampen unwanted allogeneic immunoreactions and strengthen the pro-inflammatory immune defense in non-reactive T cells, which is a frequent issue in the elderly population having a weakened immune response against invading pathogens.
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Surveillance program for former PCB-exposed workers of a transformer and capacitor recycling company, family members, employees of surrounding companies, and area residents--executive summary.
Thomas Kraus,Monika Gube,Jessica Lang,André Esser,Walter Sturm,Bruno Fimm,Klaus Willmes,Joseph Neulen,Jens M. Baron,Hans F. Merk,Thomas Schettgen,Kerstin Konrad,Sabine Deisz,Lothar Rink,Michael Hagmann,Birgit Fillies,Wolfgang Zschiesche,Jürgen Wittsiepe,Michael Wilhelm +18 more
TL;DR: In a German company polychlorinated biphenyls (PCB)-containing transformers and capacitors were recycled on a large scale, human biomonitoring revealed a high PCB body burden in workers of the recycling company, in surrounding locations of this plant, in companies in the neighborhood ofThis plant, and in family members of these employees.