L
Lothar Rink
Researcher at RWTH Aachen University
Publications - 254
Citations - 15719
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications receiving 13189 citations. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Journal ArticleDOI
Association among 1267 A/G HSP70-2, −308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population
Robertina Giacconi,Laura Costarelli,Marco Malavolta,Francesco Piacenza,Roberta Galeazzi,Nazzarena Gasparini,Andrea Basso,Erminia Mariani,Tomas Fulop,Lothar Rink,George Dedoussis,Stavroula Kanoni,Georges Herbein,Jolanta Jajte,Franco Busco,Eugenio Mocchegiani +15 more
TL;DR: Hsp70 1267 A/G SNP is associated with pro-inflammatory cytokine production in healthy elderly and might represent a possible determinant of individual susceptibility to inflammatory diseases.
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Human Neutrophils Produce Macrophage Inhibitory Protein-1β but Not Type I Interferons in Response to Viral Stimulation
TL;DR: It is concluded that neutrophils fail to prevent viral infection by IFN production but probably possess alternative mechanisms, such as secreting MIP-1beta in response to viruses.
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Zinc chelation decreases IFN-β-induced STAT1 upregulation and iNOS expression in RAW 264.7 macrophages.
Cathleen Reiber,Anne Brieger,Gabriela Engelhardt,Silke Hebel,Lothar Rink,Hajo Haase,Hajo Haase +6 more
TL;DR: Long term Zn2+ chelation does affect STAT1 protein expression, but interferes with NO production by a different, yet unknown pathway not involving STAT1, but there might still be effects on targets other than iNOS.
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Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.
Robertina Giacconi,Laura Costarelli,Marco Malavolta,Maurizio Cardelli,Roberta Galeazzi,Francesco Piacenza,Nazzarena Gasparini,Andrea Basso,Erminia Mariani,Tamas Fulop,Lothar Rink,George Dedoussis,Georges Herbein,Jolanta Jajte,Mauro Provinciali,Franco Busco,Eugenio Mocchegiani +16 more
TL;DR: New evidence is provided on the effect of ZIP2 Gln/Arg/Leu polymorphism on proinflammatory mediators and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype.
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Dendritic cell subsets in lymph nodes are characterized by the specific draining area and influence the phenotype and fate of primed T cells
Ulrike Bode,Marc Lörchner,Manuela Ahrendt,Maike Blessenohl,Kathrin Kalies,Anja Claus,Silke Overbeck,Lothar Rink,Reinhard Pabst +8 more
TL;DR: The results show that the region‐specific DC have a unique phenotype and an impact on the ratio of CD4 : CD8 T cells during an immune response in vivo.