Lothar Rink

TL;DR: The failure of MAS to induce TNF-alpha in human peripheral blood mononuclear cells is specific forMAS and not common to all superantigens, and the direct activation of bone marrow-derived macrophages also seems to be specific for MAS.

TL;DR: Combined zinc and TGF‐β1 treatment provoked an increased Treg cell induction due to a triggered intracellular zinc signal, which in association with an increased Smad 2/3 activation leads to a boosted Foxp3 expression and resulting in an ameliorated allogeneic reaction in MLC.

TL;DR: The data presented indicate that MAM-induced cytokine gene expression in human monocytes is Zn2+ dependent, and it seems that SEA and MAM interact with the same or overlapping binding sites on the MHC class II beta chain and, on the other hand, that they bind to the alpha chain most probably through the regions that are involved in SEB and TSST-1 binding.

TL;DR: TCAs might, among other mechanisms, act as antidepressants by suppressing the production of pro-inflammatory cytokines, whereas no significant effect of venlafaxine and O-desmethylvenlafAXine on IFN-γ secretion could be demonstrated.

TL;DR: The fluidity, determined by fluorescence polarization measurements, was found to decrease with decreasing temperature, suggesting that a low fluid LPS chemotype is biologically more active than a more fluid one (and vice versa), and may be one possible explanation for the higher mortality rate of hypothermic Gram-negative sepsis.