Lothar Rink

TL;DR: Cadmium can augment monocytic differentiation by activating ERK1/2 signaling, leading to increased generation of functional monocytes, which could contribute to the impact of cadmium on the immune system owing to their role in the production of pro-inflammatory cytokines and activation of T-cells by antigen presentation.

TL;DR: In conclusion, cytokine determination in MLC is a new method of evaluating the biological relevance of stimulatory antigens after allogeneic stimulation detecting all individual diversities in one experiment.

TL;DR: Microarray technology was used to assess the effects of zinc supplementation and depletion on global gene expression, and functional networks were analyzed, showing that the well known effect of zinc on pro-inflammatory cytokines is not limited to these genes; it acts on a number of functionally connected genes, as well.

TL;DR: The workshop highlighted the need to further clarify the potential public health relevance of observed nutrition-related changes in immune function, e.g. susceptibility to infections and infectious morbidity.

TL;DR: The participation of acetylation in IL-1β and TNFα promoter activation shed new light on the regulation of IL- 1β or TNF α expression and may have implications for understanding the progression from normal to disease conditions.