L
Lothar Rink
Researcher at RWTH Aachen University
Publications - 254
Citations - 15719
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications receiving 13189 citations. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
Papers
More filters
Journal ArticleDOI
Zinc signals promote IL‐2‐dependent proliferation of T cells
Jennifer Kaltenberg,Laura Marie Plum,Julia L. Ober-Blöbaum,Andrea Hönscheid,Lothar Rink,Hajo Haase +5 more
TL;DR: An increase of cytoplasmic free zinc is required for IL‐2‐induced ERK signaling and proliferation of T cells and inhibition of MEK and ERK‐dephosphorylating protein phosphatases is the molecular mechanism for the influence of zinc on this pathway.
Journal ArticleDOI
The significance of zinc for leukocyte biology.
Nele Wellinghausen,Lothar Rink +1 more
TL;DR: Data show that the zinc concentration should be taken into account whenever complex alterations of immune functions are observed and that the therapeutic use of zinc is critically discussed with new aspects also using the immunosuppressive effects of zinc.
Journal ArticleDOI
The influence of naturally occurring heterophilic anti-immunoglobulin antibodies on direct measurement of serum proteins using sandwich ELISAs.
TL;DR: It is demonstrated that two different groups of naturally occurring heterophilic antibodies (IgG-type) are responsible for false-positive IgG rheumatoid factor levels obtained using a commercially available ELISA.
Journal ArticleDOI
Zinc-Dependent Suppression of TNF-α Production Is Mediated by Protein Kinase A-Induced Inhibition of Raf-1, IκB Kinase β, and NF-κB
Verena von Bülow,Svenja Dubben,Gabriela Engelhardt,Silke Hebel,Birgit Plümäkers,Holger Heine,Lothar Rink,Hajo Haase +7 more
TL;DR: This study shows that PDE inhibition by zinc modulates the monocytic immune response by selectively intervening in the Raf-1/IKKβ/NF-κB pathway, which may constitute a common mechanism for the anti-inflammatory action of PDE inhibitors.
Journal ArticleDOI
Zinc deficiency induces production of the proinflammatory cytokines IL-1β and TNFα in promyeloid cells via epigenetic and redox-dependent mechanisms
TL;DR: Mechanisms explaining the increase in proinflammatory cytokine production during zinc deficiency are defined, focusing on the role of epigenetic and redox-mediated mechanisms.