L
Luis M. Montuenga
Researcher at University of Navarra
Publications - 245
Citations - 10844
Luis M. Montuenga is an academic researcher from University of Navarra. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 48, co-authored 221 publications receiving 9205 citations. Previous affiliations of Luis M. Montuenga include Chartered Institute of Management Accountants & Carlos III Health Institute.
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Journal ArticleDOI
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines.
Pedro P. Medina,Octavio A. Romero,Takashi Kohno,Luis M. Montuenga,Ruben Pio,Jun Yokota,Montse Sanchez-Cespedes +6 more
TL;DR: The data strongly support that BRG1 is a bona fide tumor suppressor and a major factor in lung tumorigenesis and suggest a common role in lung cancer development.
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A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer
Juan Sandoval,Jesus Mendez-Gonzalez,Ernest Nadal,Guoan Chen,F. Javier Carmona,Sergi Sayols,Sebastian Moran,Holger Heyn,Miguel Vizoso,Antonio Gomez,Montse Sanchez-Cespedes,Yassen Assenov,Fabian Müller,Christoph Bock,Miquel Taron,Josefina Mora,Lucia Anna Muscarella,Triantafillos Liloglou,Michael P.A. Davies,Marina Pollán,Maria J. Pajares,W. Torre,Luis M. Montuenga,Elisabeth Brambilla,John K. Field,Luca Roz,Marco Lo Iacono,Giorgio V. Scagliotti,Rafael Rosell,David G. Beer,Manel Esteller +30 more
TL;DR: The DNA methylation signature of NSCLC affects the outcome of stage I patients, and it can be practically determined by user-friendly polymerase chain reaction assays.
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Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.
Mercedes Garayoa,Alfredo Martínez,Sunmin Lee,Ruben Pio,Won G. An,Len Neckers,Jane B. Trepel,Luis M. Montuenga,Heather E. Ryan,Randall S. Johnson,Max Gassmann,Frank Cuttitta +11 more
TL;DR: This paper showed that the expression of AM mRNA in a variety of human tumor cell lines is highly induced in a time-dependent manner by reduced oxygen tension (1% O2) or exposure to hypoxia mimetics such as desferrioxamine mesylate (DFX) or CoCl2.
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Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression.
Leticia Corrales,Daniel Ajona,Stavros Rafail,Juan José Lasarte,Jose I Riezu-Boj,John D. Lambris,Ana Rouzaut,Maria J. Pajares,Luis M. Montuenga,Ruben Pio +9 more
TL;DR: Lung cancer cells have the capacity to generate C5a, a molecule that creates a favorable tumor microenvironment for lung cancer progression, and this molecule contributed to the immunosuppressive microenvironment required for tumor growth.
Journal ArticleDOI
Expression of Adrenomedullin and Its Receptor during Embryogenesis Suggests Autocrine or Paracrine Modes of Action
TL;DR: The developmental patterns of expression of adrenomedullin in rat and mouse embryos and the localization of the receptor paralleled that of AM itself, suggesting an autocrine or paracrine mode of action.