M
M. Paula C. Campello
Publications - 6
Citations - 182
M. Paula C. Campello is an academic researcher. The author has contributed to research in topics: DOTA & Stability constants of complexes. The author has an hindex of 6, co-authored 6 publications receiving 178 citations.
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13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: Chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation
Fernanda Marques,Lurdes Gano,M. Paula C. Campello,Sara Lacerda,Isabel Santos,Luís M. P. Lima,Judite Costa,Patricia Antunes,Rita Delgado +8 more
TL;DR: Biodistribution studies in mice demonstrated that (153)Sm/(166)Ho-trita complexes have a fast tissue clearance with more than 95% of the injected activity excreted after 2 h, value that is comparable to the corresponding dota complexes, in contrast, the ( 153)Sm-teta complex has a significantly lower total excretion.
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Lanthanide(III) complexes of 4,10-bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in solution and in the solid state: structural studies along the series.
M. Paula C. Campello,Sara Lacerda,Isabel Santos,Giovannia A. L. Pereira,Giovannia A. L. Pereira,Carlos F. G. C. Geraldes,Jan Kotek,Petr Hermann,Jakub Vaněk,Přemysl Lubal,Vojtěch Kubíček,Vojtěch Kubíček,Éva Tóth,Isabel Santos +13 more
TL;DR: In this paper, the stability constants of the divalent and trivalent metal-ion complexes are between the corresponding values of H(4)dota and H(8)dotp complexes, as a consequence of the ligand basicity.
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153Sm and 166Ho complexes with tetraaza macrocycles containing pyridine and methylcarboxylate or methylphosphonate pendant arms
Fernanda Marques,Krassimira P. Guerra,Lurdes Gano,Judite Costa,Judite Costa,M. Paula C. Campello,Luís M. P. Lima,Rita Delgado,Rita Delgado,Isabel Santos +9 more
TL;DR: A biological profile supports the in vitro instability found in serum and is consistent with the thermodynamic stability constants found for these complexes, which are hydrophilic and have a significant plasmatic protein binding.
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A novel tetraazamacrocycle bearing a thiol pendant arm for labeling biomolecules with radiolanthanides.
Sara Lacerda,M. Paula C. Campello,Fernanda Marques,Lurdes Gano,Vojtěch Kubíček,Petra Fousková,Éva Tóth,Isabel Santos +7 more
TL;DR: The novel tetraazamacrocycle 10-(2-sulfanylethyl)-1, 4,7,10-tetraazacyclodododecane-1,4,7-triacetic acid was synthesized and characterized by multinuclear NMR spectroscopy, 2D NMR techniques and mass spectrometry, finding that the thiol group does not coordinate to the metal, even in its deprotonated form.
Journal ArticleDOI
Hydrocarbyl derivatives of ucl2hb(pz)32 : synthesis, characterization and reactivity studies towards protic substrates and ketones
M. Paula C. Campello,Maria José Calhorda,Ângela Domingos,Adelino M. Galvão,João Paulo Leal,A. Pires de Matos,Isabel Santos +6 more
TL;DR: In this article, the reaction of [UCl 2 HB(pz) 3 2 ] with lithium alkyls LiR (R = Me, CH 2 SiMe 3, C 6 H 4 - o -CH 2 NMe 2 ) in the 1:1 or 1:2 molar ratio has been investigated.