Journal ArticleDOI
13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: Chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation
Fernanda Marques,Lurdes Gano,M. Paula C. Campello,Sara Lacerda,Isabel Santos,Luís M. P. Lima,Judite Costa,Patricia Antunes,Rita Delgado +8 more
Reads0
Chats0
TLDR
Biodistribution studies in mice demonstrated that (153)Sm/(166)Ho-trita complexes have a fast tissue clearance with more than 95% of the injected activity excreted after 2 h, value that is comparable to the corresponding dota complexes, in contrast, the ( 153)Sm-teta complex has a significantly lower total excretion.About:
This article is published in Journal of Inorganic Biochemistry.The article was published on 2006-02-01. It has received 61 citations till now. The article focuses on the topics: DOTA.read more
Citations
More filters
Journal ArticleDOI
Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes
TL;DR: The ligand types and structures of their complexes on one side and a set of the physico-chemical parameters governing properties of the CAs on the other side are discussed and the solid-state structures of lanthanide(III) complexes of open-chain and macrocyclic ligands and their structural features are compared.
Journal ArticleDOI
Biomedical applications of macrocyclic ligand complexes
TL;DR: The use of such complexes in imaging as MRI contrast agents, radiopharmaceuticals and luminescent probes is discussed, and the considerable scope for future development of novel metal based therapeutics based on protein binding, targeting of radioisotopes or dual function agents is highlighted.
Journal ArticleDOI
Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data
TL;DR: Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X-ray structures and theoretical studies.
Journal ArticleDOI
Enzymatic biotransformation of the azo dye Sudan Orange G with bacterial CotA-laccase
Luciana Pereira,Ana Varela Coelho,Cristina A. Viegas,Margarida M. Correia dos Santos,Maria Paula Robalo,Lígia O. Martins +5 more
TL;DR: It is shown that recombinant bacterial CotA-laccase from Bacillus subtilis is able to decolourise, at alkaline pH and in the absence of redox mediators, a variety of structurally different synthetic dyes.
Journal ArticleDOI
The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases
TL;DR: The state-of-the-art in this latest strategy for designing metal-ion chelators as potential therapeutic agents in neurodegenerative diseases will be discussed, with special emphasis on AD and additional coverage of PD and prion diseases.
References
More filters
Journal ArticleDOI
Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite of programs.
TL;DR: A new suite of 10 programs concerned with equilibrium constants and solution equilibria is described, which includes data preparation programs, pretreatment programs, equilibrium constant refinement and post-run analysis.
Book
Table of Radioactive Isotopes
TL;DR: In this paper, the authors provide a comprehensive and critical evaluation of the nuclear and atomic properties of radioactive isotopes and present detailed radiation data for about 2000 of the known nuclides.
Journal ArticleDOI
Thermodynamic and Kinetic Data for Macrocycle Interaction with Cations, Anions, and Neutral Molecules
TL;DR: In this article, the effect of macrocycle and anion parameters on the thermodynamic and kinetic stabilities of the resulting complexes is analyzed, and the results can lead to the intelligent design of new macrocycles and to predictions of their effectiveness in forming complexes of desired stability with guest species.
Journal ArticleDOI
V. S. Shirley (Ed.): Table of radioactive isotopes, Authors: E. Browne, R. B. Firestone, John Wiley + Sons, New York, Chichester, Brisbane, Toronto, Singapore 1986. Preis: £ 57.45
Journal Article
Therapeutic radionuclides : production and decay property considerations
TL;DR: It is essential that the half-life of a radionuclide used in RNT be compatible with the rates of localization in target tissues and clearance of the carrier molecule from normal tissues.
Related Papers (5)
Bifunctional chelators for therapeutic lanthanide radiopharmaceuticals.
Shuang Liu,D. S. Edwards +1 more