Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer
David D.L. Bowtell,David D.L. Bowtell,Steffen Böhm,Ahmed Ashour Ahmed,Paul Joseph Aspuria,Robert C. Bast,Valerie Beral,Jonathan S. Berek,Michael J. Birrer,Sarah P. Blagden,Michael A. Bookman,James D. Brenton,Katherine B. Chiappinelli,Filipe C. Martins,George Coukos,Ronny Drapkin,Richard J. Edmondson,Christina Fotopoulou,Hani Gabra,Jérôme Galon,Charlie Gourley,Valerie Heong,David G. Huntsman,Marcin P. Iwanicki,Beth Y. Karlan,Allyson Kaye,Ernst Lengyel,Douglas A. Levine,Karen H. Lu,Iain A. McNeish,Usha Menon,Steven A. Narod,Brad H. Nelson,Kenneth P. Nephew,Paul D.P. Pharoah,Daniel J. Powell,Pilar Ramos,Iris L. Romero,Clare L. Scott,Anil K. Sood,Euan A. Stronach,Frances R. Balkwill +41 more
TLDR
This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015 and aims to reduce incidence and improve outcomes for women with this disease.Abstract:
High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.read more
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Journal ArticleDOI
Epithelial Ovarian Cancer
TL;DR: Urgent progress is needed to develop evidence and consensus-based treatment guidelines for each subgroup, and requires close international cooperation in conducting clinical trials through academic research groups such as the Gynecologic Cancer Intergroup.
Journal ArticleDOI
Epithelial ovarian cancer: Evolution of management in the era of precision medicine
TL;DR: To improve survival in this aggressive disease, access to appropriate evidence‐based care is requisite and individualized precision medicine will require prioritizing clinical trials of innovative treatments and refining predictive biomarkers that will enable selection of patients who would benefit from chemotherapy, targeted agents, or immunotherapy.
Journal ArticleDOI
High grade serous ovarian carcinomas originate in the fallopian tube
S. Intidhar Labidi-Galy,S. Intidhar Labidi-Galy,Eniko Papp,Dorothy Hallberg,Noushin Niknafs,Noushin Niknafs,Vilmos Adleff,Michaël Noë,Rohit Bhattacharya,Rohit Bhattacharya,Marian Novak,Siân Jones,Jillian Phallen,Carolyn Hruban,Michelle S. Hirsch,Douglas I. Lin,Douglas I. Lin,Lauren E. Schwartz,Cecile L. Maire,Jean-Christophe Tille,Michaela Bowden,Ayse Ayhan,Laura D. Wood,Robert B. Scharpf,Robert J. Kurman,Tian Li Wang,Ie Ming Shih,Rachel Karchin,Rachel Karchin,Ronny Drapkin,Ronny Drapkin,Ronny Drapkin,Victor E. Velculescu +32 more
TL;DR: Genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients are analyzed and evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian cancer, with metastases following rapidly thereafter.
Journal ArticleDOI
The potential role of RNA N6-methyladenosine in Cancer progression
TL;DR: This review focuses on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
Journal ArticleDOI
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Oded Kopper,Chris J. de Witte,Kadi Lõhmussaar,Jose Espejo Valle-Inclan,Nizar Hami,Lennart Kester,Anjali Vanita Balgobind,Jeroen Korving,Natalie Proost,Harry Begthel,Lise M van Wijk,Sonia Aristín Revilla,Rebecca Theeuwsen,Marieke van de Ven,Markus J. van Roosmalen,Bas Ponsioen,Victor W.H. Ho,Benjamin G. Neel,Tjalling Bosse,Katja N. Gaarenstroom,Harry Vrieling,Maaike P.G. Vreeswijk,Paul J. van Diest,Petronella O. Witteveen,Trudy N. Jonges,Johannes L. Bos,Alexander van Oudenaarden,Ronald P. Zweemer,Hugo J. Snippert,Wigard P. Kloosterman,Hans Clevers +30 more
TL;DR: A biobank of ovarian cancer organoids recapitulates the histopathological and molecular hallmarks of patient tumors and provides a resource for preclinical research and demonstrates their potential application for research and personalized medicine.
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