T
Tommy Tong
Researcher at Sunway University
Publications - 23
Citations - 1358
Tommy Tong is an academic researcher from Sunway University. The author has contributed to research in topics: Epitope & Neutralizing antibody. The author has an hindex of 13, co-authored 20 publications receiving 1168 citations. Previous affiliations of Tommy Tong include Torrey Pines Institute for Molecular Studies.
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Journal ArticleDOI
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
Jinghe Huang,Byong H. Kang,Marie Pancera,Jeong Hyun Lee,Tommy Tong,Yu Feng,Hiromi Imamichi,Ivelin S. Georgiev,Gwo-Yu Chuang,Aliaksandr Druz,Nicole A. Doria-Rose,Leo B. Laub,Kwinten Sliepen,Marit J. van Gils,Alba Torrents de la Peña,Ronald Derking,Per Johan Klasse,Stephen A. Migueles,Robert T. Bailer,Munir Alam,Pavel Pugach,Barton F. Haynes,Richard T. Wyatt,Rogier W. Sanders,James M. Binley,Andrew B. Ward,John R. Mascola,Peter D. Kwong,Mark Connors +28 more
TL;DR: A broad and extremely potent HIV-specific monoclonal antibody, termed 35O22, which binds a novel HIV-1 envelope glycoprotein (Env) epitope, which represents a novel site of vulnerability on HIV Env, which serum analysis indicates to be commonly elicited by natural infection.
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Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals
Georgia D. Tomaras,James M. Binley,Elin S. Gray,Emma T. Crooks,Keiko Osawa,Penny L. Moore,Nancy Tumba,Tommy Tong,Xiaoying Shen,Nicole L. Yates,Julie Decker,Constantinos Kurt Wibmer,Feng Gao,S. Munir Alam,Philippa Easterbrook,Salim S. Abdool Karim,Gift Kamanga,John A. Crump,Myron S. Cohen,George M. Shaw,John R. Mascola,Barton F. Haynes,David C. Montefiori,Lynn Morris +23 more
TL;DR: The broadly reactive HIV-1 neutralization observed in some subjects is mediated by antibodies targeting several conserved regions on the HIV- 1 envelope glycoprotein.
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Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site
Ema T. Crooks,Tommy Tong,Bimal K. Chakrabarti,Kristin Narayan,Ivelin S. Georgiev,Sergey Menis,Sergey Menis,Xiaoxing Huang,Daniel W. Kulp,Daniel W. Kulp,Keiko Osawa,Janelle Muranaka,Guillaume Stewart-Jones,Guillaume Stewart-Jones,Joanne DeStefano,Sijy O'Dell,Celia C. LaBranche,James E. Robinson,David C. Montefiori,Krisha McKee,Sean X. Du,Nicole A. Doria-Rose,Peter D. Kwong,John R. Mascola,Ping Zhu,William R. Schief,William R. Schief,William R. Schief,Richard T. Wyatt,Richard T. Wyatt,Robert G. Whalen,James M. Binley +31 more
TL;DR: The data show for the first time that strain-specific holes in the glycan fence can allow the development of tier 2 neutralizing antibodies to native spikes, and cross-neutralization can occur in the absence of protecting glycan.
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Enzyme digests eliminate nonfunctional Env from HIV-1 particle surfaces, leaving native Env trimers intact and viral infectivity unaffected.
TL;DR: Remarkably, sequential glycosidase-protease digests led to a complete or near-complete removal of junk Env from many viral strains, leaving trimers and viral infectivity largely intact.
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Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential.
TL;DR: The understanding of mechanisms does not yet complete the endeavor in applying probiotics to treat MDD, but probiotics offer some advantages over standard pharmaceutical antidepressants in terms of residual symptoms, side effects and stigma involved.