R
Raija Lithovius
Researcher at University of Helsinki
Publications - 14
Citations - 449
Raija Lithovius is an academic researcher from University of Helsinki. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 7, co-authored 12 publications receiving 409 citations. Previous affiliations of Raija Lithovius include Helsinki University Central Hospital.
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Journal ArticleDOI
New susceptibility loci associated with kidney disease in type 1 diabetes.
Niina Sandholm,Niina Sandholm,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Eoin P. Brennan,Carol Forsblom,Tamara Isakova,Gareth J. McKay,Winfred W. Williams,Denise M. Sadlier,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Elizabeth Swan,Cameron D. Palmer,Cameron D. Palmer,Andrew P. Boright,Emma Ahlqvist,Harshal Deshmukh,Benjamin J. Keller,Huateng Huang,Aila J. Ahola,Emma Fagerholm,Daniel Gordin,Valma Harjutsalo,Valma Harjutsalo,Bing He,Outi Heikkilä,Kustaa Hietala,Janne P. Kytö,Päivi Lahermo,Markku Lehto,Raija Lithovius,Anne-May Österholm,Maija Parkkonen,Janne Pitkäniemi,Milla Rosengård-Bärlund,Markku Saraheimo,Cinzia Sarti,Jenny Söderlund,Aino Soro-Paavonen,Anna Syreeni,Lena M. Thorn,Heikki O. Tikkanen,Nina Tolonen,Karl Tryggvason,Jaakko Tuomilehto,Johan Wadén,Geoffrey V. Gill,Sarah L. Prior,Candace Guiducci,Daniel B. Mirel,Andrew M. Taylor,Andrew M. Taylor,S. Mohsen Hosseini,Hans-Henrik Parving,Hans-Henrik Parving,Peter Rossing,Peter Rossing,Lise Tarnow,Lise Tarnow,Claes Ladenvall,François Alhenc-Gelas,Pierre Lefebvre,Vincent Rigalleau,Ronan Roussel,David-Alexandre Trégouët,Anna Maestroni,Silvia Maestroni,Henrik Falhammar,Tianwei Gu,Anna Möllsten,D. Cimponeriu,Mihai Ioana,Maria Mota,Eugen Mota,Cristian Serafinceanu,Monica Stavarachi,Robert L. Hanson,Robert G. Nelson,Matthias Kretzler,Helen M. Colhoun,Nicolae Mircea Panduru,Harvest F. Gu,Kerstin Brismar,Gianpaolo Zerbini,Samy Hadjadj,Michel Marre,Michel Marre,Leif Groop,Maria Lajer,Shelley B. Bull,Daryl Waggott,Andrew D. Paterson,David A. Savage,Stephen C. Bain,Finian Martin,Joel N. Hirschhorn,Joel N. Hirschhorn,Catherine Godson,Jose C. Florez,Jose C. Florez,Per-Henrik Groop,Per-Henrik Groop,Alexander P. Maxwell,Alexander P. Maxwell +105 more
TL;DR: A meta-analysis of genome-wide association studies of T1D DN revealed association of two SNPs with ESRD in the AFF3 gene and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, which represent new signals in the pathogenesis of DN.
Journal ArticleDOI
Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy
Winfred W. Williams,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Niina Sandholm,Niina Sandholm,Carol Forsblom,Andrew W. Taylor,Andrew W. Taylor,Candace Guiducci,Jarred B. McAteer,Jarred B. McAteer,Gareth J. McKay,Tamara Isakova,Eoin P. Brennan,Denise M. Sadlier,Cameron D. Palmer,Cameron D. Palmer,Jenny Söderlund,Emma Fagerholm,Valma Harjutsalo,Valma Harjutsalo,Raija Lithovius,Daniel Gordin,Kustaa Hietala,Janne P. Kytö,Maija Parkkonen,Milla Rosengård-Bärlund,Lena M. Thorn,Anna Syreeni,Nina Tolonen,Markku Saraheimo,Johan Wadén,Janne Pitkäniemi,Cinzia Sarti,Jaakko Tuomilehto,Jaakko Tuomilehto,Karl Tryggvason,Anne-May Österholm,Bing He,Steve Bain,Finian Martin,Catherine Godson,Joel N. Hirschhorn,Joel N. Hirschhorn,Alexander P. Maxwell,Per-Henrik Groop,Jose C. Florez,Jose C. Florez +48 more
TL;DR: The GEnetics of Nephropathy-an International Effort (GENIE) consortium as discussed by the authors examined previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes.
Journal ArticleDOI
Smoking and progression of diabetic nephropathy in patients with type 1 diabetes
Maija Feodoroff,Valma Harjutsalo,Valma Harjutsalo,Carol Forsblom,Lena M. Thorn,Johan Wadén,Nina Tolonen,Raija Lithovius,Per-Henrik Groop,Per-Henrik Groop +9 more
TL;DR: Current smoking is a risk factor for the progression of diabetic nephropathy and the risk increases with the increasing dose of smoking, and ex-smokers seem to carry a similar risk of progression of insulin resistance as nonsmokers.
Journal ArticleDOI
Data-driven metabolic subtypes predict future adverse events in individuals with type 1 diabetes.
Raija Lithovius,Iiro Toppila,Valma Harjutsalo,Valma Harjutsalo,Carol Forsblom,Per-Henrik Groop,Per-Henrik Groop,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen +8 more
TL;DR: Data-driven multivariable metabolic subtypes predicted the divergence of complication burden across multiple clinical endpoints simultaneously and should be recognised as important subgroups in interventional studies and public health guidelines on type 1 diabetes.
Journal ArticleDOI
Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification
Francesco Sambo,Alberto Malovini,Niina Sandholm,Niina Sandholm,Monica Stavarachi,Carol Forsblom,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Valma Harjutsalo,Valma Harjutsalo,Raija Lithovius,Daniel Gordin,Maija Parkkonen,Markku Saraheimo,Lena M. Thorn,Nina Tolonen,Johan Wadén,Bing He,Anne-May Österholm,J. Tuomilehto,J. Tuomilehto,J. Tuomilehto,Maria Lajer,Rany M. Salem,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Lise Tarnow,Nicolae Mircea Panduru,Nicola Barbarini,Barbara Di Camillo,Gianna Toffolo,Karl Tryggvason,Riccardo Bellazzi,Claudio Cobelli,Per-Henrik Groop,Per-Henrik Groop +36 more
TL;DR: This study supports the previously identified findings on the RGMA/MCTP2 region and suggests novel susceptibility loci for ESRD, and highlights the importance of applying complementary statistical methods to detect novel genetic variants in diabetic nephropathy and, in general, in complex diseases.