J
Jenny Söderlund
Researcher at University of Helsinki
Publications - 9
Citations - 481
Jenny Söderlund is an academic researcher from University of Helsinki. The author has contributed to research in topics: Type 1 diabetes & Diabetic nephropathy. The author has an hindex of 7, co-authored 9 publications receiving 455 citations. Previous affiliations of Jenny Söderlund include Helsinki University Central Hospital.
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Journal ArticleDOI
New susceptibility loci associated with kidney disease in type 1 diabetes.
Niina Sandholm,Niina Sandholm,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Eoin P. Brennan,Carol Forsblom,Tamara Isakova,Gareth J. McKay,Winfred W. Williams,Denise M. Sadlier,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Elizabeth Swan,Cameron D. Palmer,Cameron D. Palmer,Andrew P. Boright,Emma Ahlqvist,Harshal Deshmukh,Benjamin J. Keller,Huateng Huang,Aila J. Ahola,Emma Fagerholm,Daniel Gordin,Valma Harjutsalo,Valma Harjutsalo,Bing He,Outi Heikkilä,Kustaa Hietala,Janne P. Kytö,Päivi Lahermo,Markku Lehto,Raija Lithovius,Anne-May Österholm,Maija Parkkonen,Janne Pitkäniemi,Milla Rosengård-Bärlund,Markku Saraheimo,Cinzia Sarti,Jenny Söderlund,Aino Soro-Paavonen,Anna Syreeni,Lena M. Thorn,Heikki O. Tikkanen,Nina Tolonen,Karl Tryggvason,Jaakko Tuomilehto,Johan Wadén,Geoffrey V. Gill,Sarah L. Prior,Candace Guiducci,Daniel B. Mirel,Andrew M. Taylor,Andrew M. Taylor,S. Mohsen Hosseini,Hans-Henrik Parving,Hans-Henrik Parving,Peter Rossing,Peter Rossing,Lise Tarnow,Lise Tarnow,Claes Ladenvall,François Alhenc-Gelas,Pierre Lefebvre,Vincent Rigalleau,Ronan Roussel,David-Alexandre Trégouët,Anna Maestroni,Silvia Maestroni,Henrik Falhammar,Tianwei Gu,Anna Möllsten,D. Cimponeriu,Mihai Ioana,Maria Mota,Eugen Mota,Cristian Serafinceanu,Monica Stavarachi,Robert L. Hanson,Robert G. Nelson,Matthias Kretzler,Helen M. Colhoun,Nicolae Mircea Panduru,Harvest F. Gu,Kerstin Brismar,Gianpaolo Zerbini,Samy Hadjadj,Michel Marre,Michel Marre,Leif Groop,Maria Lajer,Shelley B. Bull,Daryl Waggott,Andrew D. Paterson,David A. Savage,Stephen C. Bain,Finian Martin,Joel N. Hirschhorn,Joel N. Hirschhorn,Catherine Godson,Jose C. Florez,Jose C. Florez,Per-Henrik Groop,Per-Henrik Groop,Alexander P. Maxwell,Alexander P. Maxwell +105 more
TL;DR: A meta-analysis of genome-wide association studies of T1D DN revealed association of two SNPs with ESRD in the AFF3 gene and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, which represent new signals in the pathogenesis of DN.
Journal ArticleDOI
Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy
Winfred W. Williams,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Niina Sandholm,Niina Sandholm,Carol Forsblom,Andrew W. Taylor,Andrew W. Taylor,Candace Guiducci,Jarred B. McAteer,Jarred B. McAteer,Gareth J. McKay,Tamara Isakova,Eoin P. Brennan,Denise M. Sadlier,Cameron D. Palmer,Cameron D. Palmer,Jenny Söderlund,Emma Fagerholm,Valma Harjutsalo,Valma Harjutsalo,Raija Lithovius,Daniel Gordin,Kustaa Hietala,Janne P. Kytö,Maija Parkkonen,Milla Rosengård-Bärlund,Lena M. Thorn,Anna Syreeni,Nina Tolonen,Markku Saraheimo,Johan Wadén,Janne Pitkäniemi,Cinzia Sarti,Jaakko Tuomilehto,Jaakko Tuomilehto,Karl Tryggvason,Anne-May Österholm,Bing He,Steve Bain,Finian Martin,Catherine Godson,Joel N. Hirschhorn,Joel N. Hirschhorn,Alexander P. Maxwell,Per-Henrik Groop,Jose C. Florez,Jose C. Florez +48 more
TL;DR: The GEnetics of Nephropathy-an International Effort (GENIE) consortium as discussed by the authors examined previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes.
Journal ArticleDOI
Soluble receptor for AGE (RAGE) is a novel independent predictor of all-cause and cardiovascular mortality in type 1 diabetes
Merlin C. Thomas,Jenny Söderlund,Jenny Söderlund,Markku Lehto,Ville-Petteri Mäkinen,John Moran,Mark E. Cooper,Carol Forsblom,Carol Forsblom,Per-Henrik Groop,Per-Henrik Groop +10 more
TL;DR: Increased concentrations of sRAGE are associated with increased all-cause and cardiovascular mortality in type 1 diabetes, potentially reflecting the activation and production of RAGE in the context of accelerated vascular disease.
Journal ArticleDOI
Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes
Josephine M. Forbes,Josephine M. Forbes,Jenny Söderlund,Jenny Söderlund,Felicia Y. T. Yap,Mikael Knip,Sofianos Andrikopoulos,Jorma Ilonen,Jorma Ilonen,Olli Simell,Riitta Veijola,Karly C. Sourris,Melinda T. Coughlan,Carol Forsblom,Carol Forsblom,Robyn Maree Slattery,Shane T. Grey,Maija Wessman,Hiroshi Yamamoto,Angelika Bierhaus,Mark E. Cooper,Mark E. Cooper,Per-Henrik Groop,Per-Henrik Groop,Per-Henrik Groop +24 more
TL;DR: These studies suggest that inherited AGER gene polymorphisms may confer susceptibility to environmental insults, and declining circulating levels of soluble RAGE, before the development of overt diabetes, may also be predictive of clinical disease in children with high to medium risk HLA II backgrounds.
Journal ArticleDOI
Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes
Lena M. Thorn,Carol Forsblom,Johan Wadén,Jenny Söderlund,Milla Rosengård-Bärlund,Markku Saraheimo,Outi Heikkilä,Kustaa Hietala,K. Pettersson-Fernholm,Jorma Ilonen,Per-Henrik Groop +10 more
TL;DR: Parental history of type 2 diabetes is associated with a later onset of type 1 diabetes, the metabolic syndrome, and a metabolic profile related to insulin resistance and no association was observed with blood pressure, diabetes complications, or HLA genotype distribution.