Edward Salinas

TL;DR: The OECD validation study of the zebrafish embryo acute toxicity test (ZFET) for acute aquatic toxicity testing evaluated the ZFET reproducibility by testing 20 chemicals at 5 different concentrations in 3 independent runs in at least 3 laboratories, showing that the ZfET is a robust method with a good intra- and inter-laboratory reproducible for most chemicals and laboratories.

TL;DR: An overview on current regulations of chemicals and the requirements for animal tests in environmental hazard and risk assessment is provided and the potential areas for alternative approaches to animal tests using vertebrates in environmental toxicology are highlighted.

TL;DR: The goal of reducing animal testing of endocrine disruptors, in vivo embryo assays offer an ethical alternative to corroborate mammalian toxicity results and address environmental protection goals for aquatic vertebrates Timely Scientifi c Opinions In a Nutshell.