Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Dominick E. Shaw,Ana R. Sousa,Stephen J. Fowler,Louise Fleming,Graham Roberts,Graham Roberts,Julie Corfield,Julie Corfield,Ioannis Pandis,Aruna T. Bansal,Elisabeth H. Bel,Charles Auffray,Chris Compton,Hans Bisgaard,Enrica Bucchioni,Massimo Caruso,Pascal Chanez,Barbro Dahlén,Sven-Erik Dahlén,Kerry Dyson,Urs Frey,Thomas Geiser,Maria Gerhardsson de Verdier,David Gibeon,Yike Guo,Simone Hashimoto,Gunilla Hedlin,E. Jeyasingham,P.P. Hekking,Tim Higenbottam,Ildiko Horvath,Alan J. Knox,Norbert Krug,Veit J. Erpenbeck,L. Larsson,Nikos Lazarinis,John G. Matthews,Roelinde Middelveld,Paolo Montuschi,Jacek Musiał,David Myles,Laurie Pahus,Thomas Sandström,Wolfgang Seibold,Florian Singer,Karin Strandberg,Jørgen Vestbo,Nadja Hawwa Vissing,Christophe von Garnier,Ian M. Adcock,Scott Wagers,Anthony Rowe,Peter H. Howarth,Ariane H. Wagener,Ratko Djukanovic,Peter J. Sterk,Kian Fan Chung +56 more
TLDR
U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment, and is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.Abstract:
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.read more
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Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma.
Klaus F. Rabe,Parameswaran Nair,Guy Brusselle,Jorge Maspero,Mario Castro,Lawrence Sher,Hongjie Zhu,Jennifer D. Hamilton,Brian N. Swanson,Asif Khan,Asif Khan,Jingdong Chao,Heribert Staudinger,Gianluca Pirozzi,Christian Antoni,Nikhil Amin,Marcella Ruddy,Bolanle Akinlade,Neil M.H. Graham,Neil Stahl,George D. Yancopoulos,Ariel Teper +21 more
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Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma.
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Chih-Hsi Scott Kuo,Chih-Hsi Scott Kuo,Stelios Pavlidis,Matthew J. Loza,F. Baribaud,Anthony Rowe,Iaonnis Pandis,Ana C. A. Sousa,Julie Corfield,Julie Corfield,Ratko Djukanovic,René Lutter,Peter J. Sterk,C. Auffray,C. Auffray,Yike Guo,Ian M. Adcock,Kian Fan Chung +17 more
TL;DR: The objective was to determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from 104 moderate-to-severe asthmatic subjects and 16 nonasthmatic subjects, finding one Th2-high eosinophilic phenotype TAC1, and two non-Th2 phenotypes TAC2 and TAC3, characterised by inflammasome-associated and metabolic/mitochondrial pathways, respectively.
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