Matej Orešič

TL;DR: It is shown that rhythmic transcription extends to the locus specifying miR-122, a highly abundant, hepatocyte-specific microRNA, and the identification of Pparbeta/delta and the peroxisome proliferator-activated receptor alpha (PPARalpha) coactivator Smarcd1/Baf60a as novel miR,122 targets suggests an involvement of the circadian metabolic regulators of the PPAR family in miR -122-mediated metabolic control.

TL;DR: Similar increases in liver fat and NASH are associated with a metabolically harmful saturated, ceramide-enriched liver lipidome in 'Metabolic NAFLD' but not in 'PNPLA3NAFLD', which may explain why metabolic but not PNPLA3 NAFLd increases the risk of type 2 diabetes and cardiovascular disease.

TL;DR: Several methods of pathway analysis are reviewed and the performance of three, the binomial distribution, z scores, and gene set enrichment analysis, on two microarray datasets are compared.

TL;DR: A comprehensive profiling analysis of the Madagascar periwinkle (Catharanthus roseus), a source of the anticancer drugs vinblastine and vincristine, provides the basis for a better understanding of periwinkles secondary metabolism and increases the practical potential of metabolic engineering of this important medicinal plant.

TL;DR: Adipose tissue is infiltrated with macrophages, and its content of long-chain triacylglycerols and ceramides is increased in subjects with increased LFAT compared with equally obese subjects with normal LFAT content, which could contribute to adverse effects of long chain fatty acids on insulin resistance and inflammation.