M
Matej Orešič
Researcher at Örebro University
Publications - 390
Citations - 32818
Matej Orešič is an academic researcher from Örebro University. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 82, co-authored 352 publications receiving 26830 citations. Previous affiliations of Matej Orešič include University of Iceland & University of Turku.
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Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.
TL;DR: A method for efficient treatment of large data sets produced by GC×GC/TOFMS implemented as a freely available open source software package, Guineu, successfully used for the analysis of several thousand samples in the field of metabolomics is presented.
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Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
María Isabel Hernández-Alvarez,David Sebastián,David Sebastián,Sara Vives,Saška Ivanova,Saška Ivanova,Paola Bartoccioni,Pamela A. Kakimoto,Natàlia Plana,Sonia R. Veiga,Vanessa Hernández,Nuno Vasconcelos,Gopal Peddinti,Anna Adrover,Mariona Jové,Reinald Pamplona,Isabel Gordaliza-Alaguero,Isabel Gordaliza-Alaguero,Enrique Calvo,Noemí Cabré,Rui E. Castro,Antonija Kuzmanic,Marie Boutant,David Sala,Tuulia Hyötyläinen,Matej Orešič,Joana Fort,Joana Fort,Ekaitz Errasti-Murugarren,Cecília M. P. Rodrigues,Modesto Orozco,Jorge Joven,Carles Cantó,Manuel Palacín,Manuel Palacín,Sonia Fernández-Veledo,Joan Vendrell,Antonio Zorzano,Antonio Zorzano +38 more
TL;DR: It is demonstrated that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease and binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrialosphatidylethanolamine (PE) synthesis.
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Ketogenic diet slows down mitochondrial myopathy progression in mice
Sofia Tuulikki Ahola-Erkkilä,Christopher Carroll,Katja E. Peltola-Mjosund,Valtteri Tulkki,Ismo Mattila,Tuulikki Seppänen-Laakso,Matej Orešič,Henna Tyynismaa,Anu Suomalainen,Anu Suomalainen +9 more
TL;DR: The results show that mitochondrial myopathy induces widespread metabolic changes, and that ketogenic diet can slow down progression of the disease in mice, and suggest that KD may be useful for mitochondrial late-onset myopathies.
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Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data
Leo Lahti,Leo Lahti,Anne Salonen,Riina A. Kekkonen,Jarkko Salojärvi,Jonna Jalanka-Tuovinen,Airi Palva,Matej Orešič,Willem M. de Vos,Willem M. de Vos +9 more
TL;DR: The results suggest that several members of the Firmicutes, Actinobacteria and Proteobacteria may be involved in the metabolism of dietary and endogenous lipids, and provide a scientific rationale for further human studies to explore the role of intestinal microbes in host lipid metabolism.
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Lipidomics: a new window to biomedical frontiers
TL;DR: An alternative strategy is to focus on tissues with limited allostatic capacity, such as the eye, that could be used as readouts of metabolic stress over time and provide a window to unknown pathogenic mechanisms, as well as facilitate identification of early biomarkers of disease.