M
Matej Orešič
Researcher at Örebro University
Publications - 390
Citations - 32818
Matej Orešič is an academic researcher from Örebro University. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 82, co-authored 352 publications receiving 26830 citations. Previous affiliations of Matej Orešič include University of Iceland & University of Turku.
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Journal ArticleDOI
Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome
Kajsa Kajander,Eveliina Myllyluoma,Sinikka Kyrönpalo,Martin Rasmussen,Pentti Sipponen,Ismo Mattila,Tuulikki Seppänen-Laakso,Heikki Vapaatalo,Matej Orešič,Riitta Korpela +9 more
TL;DR: IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile, and there was an increase in several lipid species such as lysophospholipids and ceramides.
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The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice.
TL;DR: The data suggest that germ-free NOD mice have reduced glycaemic control and dysregulated immunologic and metabolic responses, which are similar to that of pre-diabetic children.
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Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites.
Claudia Vetrani,Angela A. Rivellese,Giovanni Annuzzi,Martin Adiels,Jan Borén,Ismo Mattila,Matej Orešič,Anna-Marja Aura +7 more
TL;DR: Comparing in vitro microbial phenolic metabolite profile of foods and beverages with that excreted in urine of subjects consuming the same foodstuff and exploring the role of liver on postcolonic metabolism of polyphenols by using in vitro hepatic models may better elucidate the metabolism ofpolyphenols from dietary exposure to urinary metabolites.
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Metabolic alterations in immune cells associate with progression to type 1 diabetes
Partho Sen,Alex M. Dickens,María Asunción López-Bascón,María Asunción López-Bascón,Tuomas Lindeman,Esko Kemppainen,Santosh Lamichhane,Tuukka Rönkkö,Jorma Ilonen,Jorma Ilonen,Jorma Toppari,Jorma Toppari,Riitta Veijola,Riitta Veijola,Riitta Veijola,Heikki Hyöty,Tuulia Hyötyläinen,Mikael Knip,Matej Orešič,Matej Orešič +19 more
TL;DR: The data suggest that systemic dysregulation of lipid metabolism, as observed in plasma, may impact the metabolism and function of immune cells during progression to overt type 1 diabetes.
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15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells.
Laura Lehtinen,Paula Vainio,Harriet Wikman,Johannes Reemts,Mika Hilvo,Rana Issa,Sirkku Pollari,Burkhard Brandt,Matej Orešič,Klaus Pantel,Olli Kallioniemi,Olli Kallioniemi,Kristiina Iljin +12 more
TL;DR: HPGD mRNA is overexpressed in a subset of clinical breast cancers compared to normal breast tissue samples and that high HPGD mRNA expression associates with poor prognosis, and results indicate that HPGD is highly expressed in metastatic and aggressive breast cancer and promotes EMT and migration in breast cancer cells.