Matej Orešič

TL;DR: Serum metabolite profiles were compared between sample series drawn from children who progressed to type 1 diabetes and controls who remained nondiabetic and permanently autoantibody negative, finding that autoimmunity may be a relatively late response to the early metabolic disturbances.

TL;DR: The narrow range of chemical analyses in current use by the medical community today will be replaced in the future by analyses that reveal a far more comprehensive metabolic signature, expected to describe global biochemical aberrations that reflect patterns of variance in states of wellness, more accurately describe specific diseases and their progression, and greatly aid in differential diagnosis.

TL;DR: This work developed and implemented a new recursive peak search algorithm and a secondary peak picking method for improving already aligned results, as well as a normalization tool that uses multiple internal standards.

TL;DR: Results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.

TL;DR: The results indicate that the PPARg2 isoform plays an important role, mediating adipose tissue expansion in response to positive energy balance, and may be required for the β-cell hypertrophic adaptive response to insulin resistance.