M
Matej Orešič
Researcher at Örebro University
Publications - 390
Citations - 32818
Matej Orešič is an academic researcher from Örebro University. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 82, co-authored 352 publications receiving 26830 citations. Previous affiliations of Matej Orešič include University of Iceland & University of Turku.
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Journal ArticleDOI
Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects
Sergio Rodriguez-Cuenca,Christopher J. Lelliot,Mark Campbell,Gopal Peddinti,Maite Martínez-Uña,Camilla Ingvorsen,Ana Rita Dias,Joana Relat,Silvia Mora,Tuulia Hyötyläinen,Antonio Zorzano,Antonio Zorzano,Matej Orešič,Matej Orešič,Mikael Bjursell,Mohammad Bohlooly-Y,Daniel Lindén,Daniel Lindén,Antonio Vidal-Puig,Antonio Vidal-Puig +19 more
TL;DR: In this article, double heterozygous (DH) mice were studied to investigate their combined pathogenic contribution and the existence of organ-specific compensatory allostatic mechanisms are robust enough to drive an unexpected phenotype.
Posted ContentDOI
Quantitative genome-scale analysis of human liver reveals dysregulation of glycosphingolipid pathways in progressive nonalcoholic fatty liver disease
Partho Sen,Partho Sen,Olivier Govaere,Tim Sinioja,Aidan McGlinchey,Dawei Geng,Ratziu,Elisabetta Bugianesi,Jörn M. Schattenberg,Antonio Vidal-Puig,Michael Allison,Simon Cockell,Ann K. Daly,Tuulia Hyötyläinen,Quentin M. Anstee,Quentin M. Anstee,Matej Orešič,Matej Orešič +17 more
TL;DR: In this article, the authors examined the metabolic pathways of the human liver across the full histological spectrum of nonalcoholic fatty liver disease (NAFLD) and identified several metabolic signatures in the liver and blood of these patients.
Proceedings ArticleDOI
Abstract 5573: GC-TOF mass spectroscopy reveals strong dependence of breast cancer metabolome on estrogene receptor, but not on HER2 status
Jan Budczies,Carsten Denkert,Berit Maria Müller,Manfred Dietel,Cornelia Radke,Jules L. Griffin,Matej Orešič,Gert Wohlgemut,Oliver Fiehn +8 more
TL;DR: It is shown that metabolic profiling of fresh-frozen breast cancer samples with GC-MS is feasible and a strong dependence of the metabolite patterns on ER status, but no dependence on HER2 status is detected.
Posted ContentDOI
Dysregulated lipid metabolism precedes onset of psychosis in people at clinical high risk
Alex M. Dickens,Partho Sen,Matthew J. Kempton,Neus Barrantes-Vidal,Conrad Iyegbe,Merete Nordentoft,Thomas A Pollak,Anita Riecher-Rössler,Stephan Ruhrmann,Gabriele Sachs,Rodrigo A. Bressan,Marie-Odile Krebs,de Haan L,van der Gaag M,Lucia Valmaggia,Tuulia Hyötyläinen,Matej Orešič,Matej Orešič,Phillip McGuire +18 more
TL;DR: It is suggested that lipidomic abnormalities predate the onset of psychosis, and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.
Posted ContentDOI
Circulating lipids associate with future weight gain in individuals with an at-risk mental state and in first-episode psychosis
Santosh Lamichhane,Alex M. Dickens,Partho Sen,Heikki Laurikainen,Jaana Suvisaari,Tuulia Hyötyläinen,Oliver D. Howes,Oliver D. Howes,Jarmo Hietala,Matej Orešič,Matej Orešič +10 more
TL;DR: It is concluded that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals, and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic co-morbidities.