Matej Orešič

TL;DR: Significant species-specific correlations between the use of two synonymous codons and protein secondary structure units are found by comparing the three-dimensional structures of human and Escherichia coli proteins with their mRNA sequences to help identify residues that are important for secondary structure formation.

TL;DR: The ELF test showed high sensitivity but limited specificity to exclude advanced and significant fibrosis at low cutoffs and the diagnostic performance of the test at higher thresholds was found to be more limited in low prevalence settings.

TL;DR: It is suggested that VEGF-B regulates lipid metabolism, an unexpected function for an angiogenic growth factor, in heart mice expressing a cardiac-specific VEGf-B transgene via the α-myosin heavy chain promoter.

TL;DR: In this paper, the absence of microsomal triglyceride transfer protein (Mttp) in the liver was found to cause hepatic steatosis and increased ceramides and diacylglycerols in mice.

TL;DR: In this paper, the authors look at standards for data sharing, investigate their impact in metabolomics and give suggestions to improve their adoption, including new opportunities to publish data sets, but also require a little "arm twisting" in the author guidelines of scientific journals to submit the data sets to public repositories such as the NIH Metabolomics Workbench or MetaboLights at EMBL-EBI.