M
Matej Orešič
Researcher at Örebro University
Publications - 390
Citations - 32818
Matej Orešič is an academic researcher from Örebro University. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 82, co-authored 352 publications receiving 26830 citations. Previous affiliations of Matej Orešič include University of Iceland & University of Turku.
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Journal ArticleDOI
Tracing specific synonymous codon-secondary structure correlations through evolution.
TL;DR: The GAU-α-helix correlation is also strong in non-human mammalian and vertebrate proteins but is much weaker or insignificant in S. cerevisiae and plants, suggesting the existence of a novel evolutionary selection mechanism.
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Deep learning meets metabolomics: a methodological perspective.
Partho Sen,Partho Sen,Santosh Lamichhane,Vivek Bhakta Mathema,Aidan McGlinchey,Alex M. Dickens,Sakda Khoomrung,Matej Orešič,Matej Orešič +8 more
TL;DR: The DL-based approaches discussed here may assist computational biologists with the integration, prediction and drawing of statistical inference about biological outcomes, based on metabolomics data.
Journal ArticleDOI
Peroxisome Proliferator-Activated Receptor γ-Dependent Regulation of Lipolytic Nodes and Metabolic Flexibility
Sergio Rodriguez-Cuenca,Stefania Carobbio,Vidya Velagapudi,Nuria Barbarroja,José María Moreno-Navarrete,Francisco J. Tinahones,José Manuel Fernández-Real,Matej Orešič,Antonio Vidal-Puig +8 more
TL;DR: The data indicate that PPARγ is required for activation of the lipolytic regulatory network, dysregulation of which is an important feature of obesity-induced insulin resistance in humans.
Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity
Stefania Carobbio,Rachel M. Hagen,Christopher J. Lelliott,Marc Slawik,Marc Slawik,Gema Medina-Gómez,Gema Medina-Gómez,Chong Yew Tan,Audrey Sicard,Helen J. Atherton,Nuria Barbarroja,Nuria Barbarroja,Mikael Bjursell,Mohammad Bohlooly-Y,Sam Virtue,Antoinette Tuthill,Etienne Lefai,Martine Laville,Tingting Wu,Robert V. Considine,Hubert Vidal,Dominique Langin,Matej Orešič,Francisco J. Tinahones,José Manuel Fernández-Real,Julian L. Griffin,Jaswinder K. Sethi,Miguel López,Miguel López,Antonio Vidal-Puig,Antonio Vidal-Puig +30 more
TL;DR: In this article, changes in the regulatory feedback set point control of Insig1/SREBP1 represent an adaptive response that preserves WAT lipid homeostasis in obese and insulin-resistant states.
Journal ArticleDOI
Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease
Partho Sen,Partho Sen,Sami Qadri,Sami Qadri,Panu K. Luukkonen,Panu K. Luukkonen,Panu K. Luukkonen,Oddny Ragnarsdottir,Aidan McGlinchey,Sirkku Jäntti,Anne Juuti,Johanna Arola,Jennifer J. Schlezinger,Thomas F. Webster,Matej Orešič,Matej Orešič,Hannele Yki-Järvinen,Hannele Yki-Järvinen,Tuulia Hyötyläinen +18 more
TL;DR: In this article, the effects of environmental contaminants (ECs) exposure on liver metabolism were investigated in a non-alcoholic fatty liver disease (NAFLD) cohort of 105 individuals, and the results showed that exposure to ECs, particularly perfluorinated alkyl substances (PFAS), impacts liver metabolism, specifically bile acid metabolism.