M
Matilde Todaro
Researcher at University of Palermo
Publications - 163
Citations - 19136
Matilde Todaro is an academic researcher from University of Palermo. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 55, co-authored 154 publications receiving 17289 citations. Previous affiliations of Matilde Todaro include University of Rome Tor Vergata.
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Journal ArticleDOI
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani,Dario Giuseppe Lombardi,Emanuela Pilozzi,Mauro Biffoni,Matilde Todaro,Cesare Peschle,Ruggero De Maria +6 more
TL;DR: It is concluded that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies.
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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Louis Vermeulen,Felipe De Sousa E Melo,Maartje van der Heijden,Kate Cameron,Joan H. de Jong,Tijana Borovski,Jurriaan B. Tuynman,Matilde Todaro,Christian Merz,Hans M. Rodermond,Martin R. Sprick,Kristel Kemper,Dick J. Richel,Giorgio Stassi,Jan Paul Medema +14 more
TL;DR: It is proposed that stemness of colon cancer cells is in part orchestrated by the microenvironment and is a much more dynamic quality than previously expected that can be defined by high Wnt activity.
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Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Lucia Ricci-Vitiani,Roberto Pallini,Mauro Biffoni,Matilde Todaro,Gloria Invernici,Tonia Cenci,Giulio Maira,Eugenio Parati,Giorgio Stassi,Luigi Maria Larocca,Ruggero De Maria +10 more
TL;DR: A variable number (range 20–90%, mean 60.7%) of endothelial cells in glioblastoma carry the same genomic alteration as tumour cells, indicating that a significant portion of the vascular endothelium has a neoplastic origin.
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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.
Matilde Todaro,Mileidys Perez Alea,Anna Barbara Di Stefano,Patrizia Cammareri,Louis Vermeulen,Flora Iovino,Claudio Tripodo,Antonio Russo,Gaspare Gulotta,Jan Paul Medema,Giorgio Stassi +10 more
TL;DR: The data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4, which strongly enhances the antitumor efficacy of standard chemotherapeutic drugs through selective sensitization of CD133(+) cells.
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Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
Louis Vermeulen,Matilde Todaro,F. De Sousa Mello,Martin R. Sprick,Kristel Kemper,M. Perez Alea,Dirk J. Richel,Giorgio Stassi,Jan Paul Medema +8 more
TL;DR: In this article, the authors show that spheroid cultures of these colon CSCs contain expression of CD133, CD166, CD44, CD29, CD24, Lgr5, and nuclear β-catenin, which have all been suggested to mark the cancer stem cell population.