Matt C. Danzi

TL;DR: It is shown that extracellular vesicles containing NOX2 complexes are released from macrophages and incorporated into injured axons, leading to axonal regeneration through PI3K–p-Akt signalling, challenging the view that ROS are exclusively involved in nerve degeneration.

TL;DR: It is shown that TNFR2 ablation in microglia leads to early onset of EAE with increased leukocyte infiltration, T cell activation, and demyelination in the central nervous system (CNS).

TL;DR: Functional studies suggest that SORD deficiency may be treatable with aldose reductase inhibitors and may contribute to a better understanding of the pathophysiology of diabetes.

TL;DR: Using transgenic mice that allow reliable visualization of axonal fate, it is demonstrated that intrinsically photosensitive retinal ganglion cells (ipRGCs) are both resilient to cell death and highly regenerative.

TL;DR: It was found that placing mice in an enriched environment before an injury enhanced the activity of proprioceptive dorsal root ganglion neurons, leading to a lasting increase in their regenerative potential, dependent on Creb-binding protein (Cbp)–mediated histone acetylation, which increased the expression of genes associated with the regenerative program.