Mehran Taherian

TL;DR: The landscape of gene expression across tissues is described, thousands of tissue-specific and shared regulatory expression quantitative trait loci (eQTL) variants are cataloged, complex network relationships are described, and signals from genome-wide association studies explained by eQTLs are identified.

TL;DR: In this article, the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondria biology is observed in many tissues, and different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on principal component analysis.

TL;DR: It is shown that TNFR2 ablation in microglia leads to early onset of EAE with increased leukocyte infiltration, T cell activation, and demyelination in the central nervous system (CNS).

TL;DR: It is demonstrated that mtDNA damage can cause primary oligodendropathy, which in turn triggers demyelination, proving PLP:mtPstI mice to be a useful tool to study the pathological consequences of mitochondrial dysfunction in oligod endonuclease, as well as an ideal platform to test remyelinating and neuroprotective agents.

TL;DR: Evaluation of performance of this intelligent fuzzy system reinforces that the system’s results not only correspond with the evaluations of experienced asthma physicians, but represents slight differences in the levels of asthma control between asthmatic patients.