M
Matthew G. Oser
Researcher at Harvard University
Publications - 30
Citations - 3600
Matthew G. Oser is an academic researcher from Harvard University. The author has contributed to research in topics: Invadopodia & Cortactin. The author has an hindex of 18, co-authored 27 publications receiving 2983 citations. Previous affiliations of Matthew G. Oser include Albert Einstein College of Medicine & Yeshiva University.
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Journal ArticleDOI
Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin
TL;DR: Clinical observations and biology underlying tumours with combined SCLC and NSCLC histology and cancers that transform from adenocarcinoma to S CLC are summarized.
Journal ArticleDOI
Polycomb Group Protein Ezh2 Controls Actin Polymerization and Cell Signaling
I-hsin Su,Marc-Werner Dobenecker,Ephraim Dickinson,Matthew G. Oser,Ashwin Basavaraj,Raphael Marqueron,Agnes Viale,Danny Reinberg,Christoph Wülfing,Alexander Tarakhovsky +9 more
TL;DR: The existence of the cytosolic polycomb group protein Ezh2-containing methyltransferase complex and the function of this complex to regulation of actin polymerization in various cell types was reported in this paper.
Journal ArticleDOI
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
Matthew G. Oser,Hideki Yamaguchi,Hideki Yamaguchi,Christopher C. Mader,Jose Javier Bravo-Cordero,Marianela Arias,Xiaoming Chen,Vera DesMarais,Jacco van Rheenen,Jacco van Rheenen,Anthony J. Koleske,John S. Condeelis +11 more
TL;DR: The stages of invadopodium assembly and maturation are dissected and it is shown thatInvadopodia use cortactin phosphorylation as a master switch during these processes to regulate cofilin and Arp2/3 complex–dependent actin polymerization.
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An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion
Christopher C. Mader,Matthew G. Oser,Marco A. O. Magalhaes,Jose Javier Bravo-Cordero,John S. Condeelis,Anthony J. Koleske,Hava Gil-Henn +6 more
TL;DR: Evidence is provided that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growth factor (EGF)-induced cortactin phosphorylation, triggering actin polymerization in invadopodia, ECM degradation, and matrix proteolysis-dependent tumor cell invasion.
Journal ArticleDOI
A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
Ulrike Philippar,Evanthia T. Roussos,Matthew G. Oser,Hideki Yamaguchi,Hideki Yamaguchi,Hyung-Do Kim,Silvia Giampieri,Yarong Wang,Sumanta Goswami,Sumanta Goswami,Jeffrey B. Wyckoff,Douglas A. Lauffenburger,Erik Sahai,Erik Sahai,John S. Condeelis,Frank B. Gertler +15 more
TL;DR: It is shown that Mena and Mena(INV) promote carcinoma cell motility and invasiveness in vivo and in vitro, and increase lung metastasis and EGF-induced membrane protrusion of tumor cells.