M
Menno ter Huurne
Researcher at Radboud University Nijmegen
Publications - 13
Citations - 1775
Menno ter Huurne is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 9, co-authored 12 publications receiving 1361 citations. Previous affiliations of Menno ter Huurne include Royal Children's Hospital & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed,Jessica Quintin,Hindrik H. D. Kerstens,Nagesha A.S. Rao,Ali Aghajanirefah,Filomena Matarese,Shih-Chin Cheng,Jacqueline M. Ratter,Kim Berentsen,Martijn van der Ent,Nilofar Sharifi,Eva M. Janssen-Megens,Menno ter Huurne,Amit Mandoli,Tom van Schaik,Aylwin Ng,Aylwin Ng,Frances Burden,Kate Downes,Mattia Frontini,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Willem H. Ouwehand,Jos W. M. van der Meer,Leo A. B. Joosten,Cisca Wijmenga,Joost H.A. Martens,Ramnik J. Xavier,Ramnik J. Xavier,Colin Logie,Mihai G. Netea,Hendrik G. Stunnenberg +31 more
TL;DR: The epigenetic and transcriptional programs of monocyte differentiation to macrophages that distinguish tolerant and trained macrophage phenotypes are uncovered, providing a resource to further understand and manipulate immune-mediated responses.
Journal ArticleDOI
Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis.
Menno ter Huurne,R. Schelbergen,Roxane Blattes,Arjen B. Blom,Wouter de Munter,Lilyanne C. Grevers,Jannik Jeanson,Danièle Noël,Louis Casteilla,Christian Jorgensen,Wim B. van den Berg,Peter L. E. M. van Lent +11 more
TL;DR: Findings indicate that a single injection of ASCs into the knee joints of mice with early-stage collagenase-induced OA inhibits synovial thickening, formation of enthesophytes associated with ligaments, and cartilage destruction.
Journal ArticleDOI
Distinct cell cycle control in two different states of mouse pluripotency
TL;DR: It is shown that ESCs grown in the presence of two small-molecule inhibitors (2i ESCs) have a longer G1-phase with hypo-phosphorylated RB, implying that they have a functional G1 checkpoint, and RB-dependent G1 restriction point signaling is active in mouse ESCs growing in 2i but abrogated in serum by ERK-dependent phosphorylation.
Journal ArticleDOI
The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
Ning Qing Liu,Menno ter Huurne,Luan Nguyen,Tianran Peng,Shuang-Yin Wang,James B. Studd,Onkar Joshi,Halit Ongen,Jesper B. Bramsen,Jian Yan,Jian Yan,Claus L. Andersen,Jussi Taipale,Emmanouil T. Dermitzakis,Richard S. Houlston,Nina C. Hubner,Hendrik G. Stunnenberg +16 more
TL;DR: A large-scale PWAS study is performed to comprehensively characterize TF-binding landscape that is associated with CRC, which identifies 731 allele-specific TF binding at 116 CRC risk loci.
Journal ArticleDOI
The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs
Amit Mandoli,Abhishek Singh,Koen H.M. Prange,Esther Tijchon,Marjolein M. P. Oerlemans,René A.M. Dirks,Menno ter Huurne,Albertus T. J. Wierenga,Eva M. Janssen-Megens,Kim Berentsen,Nilofar Sharifi,Bowon Kim,Filomena Matarese,Luan Nguyen,Nina C. Hubner,Nagesha A.S. Rao,Emile van den Akker,Lucia Altucci,Edo Vellenga,Hendrik G. Stunnenberg,Joost H.A. Martens,Joost H.A. Martens +21 more
TL;DR: It is found that expression of wild-type transcription factors RUNX1 and ERG in AML is required to prevent this oncogene overexpression, and the interplay of the epigenome and transcription factors prevents apoptosis in t(8;21) AML cells.