M
Michael C. Neale
Researcher at Virginia Commonwealth University
Publications - 647
Citations - 72612
Michael C. Neale is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Twin study & Population. The author has an hindex of 121, co-authored 620 publications receiving 66343 citations. Previous affiliations of Michael C. Neale include VU University Amsterdam & University of East London.
Papers
More filters
Journal ArticleDOI
Factor and item-response analysis DSM-IV criteria for abuse of and dependence on cannabis, cocaine, hallucinogens, sedatives, stimulants and opioids.
TL;DR: The DSM-IV abuse and dependence criteria, within each drug class, are not distinct but best described in terms of a single underlying continuum of risk, best explained by a single factor.
Journal ArticleDOI
Sexual dimorphism in innate immunity.
George Moxley,Danielle Posthuma,Patricia Carlson,Eloise Estrada,Jinfeng Han,Linda L. Benson,Michael C. Neale +6 more
TL;DR: Female subjects have a nearly 30% lower innate immune response, stemming largely from influence independent of the HLA-region TNF locus and without further independent variation stemming from plasma estrogen level.
Journal ArticleDOI
Catechol-O-Methyltransferase Contributes to Genetic Susceptibility Shared Among Anxiety Spectrum Phenotypes
John M. Hettema,Seon-Sook An,József Bukszár,Edwin J. C. G. van den Oord,Michael C. Neale,Kenneth S. Kendler,Xiangning Chen +6 more
TL;DR: Variations in the COMT gene contribute to genetic risk shared across a range of anxiety-related phenotypes, and these findings are female-specific.
Journal ArticleDOI
Variants in nicotinic acetylcholine receptors α5 and α3 increase risks to nicotine dependence
Xiangning Chen,Jingchun Chen,Vernell Williamson,Seon-Sook An,John M. Hettema,Steven H. Aggen,Michael C. Neale,Kenneth S. Kendler +7 more
TL;DR: The results suggested that the α5 and α3 subunits play a significant role in both nicotine dependence and alcohol abuse/dependence, however, the opposite effects with nicotine dependence, alcohol abuse or dependence were puzzling and future studies are necessary to resolve this issue.
Journal ArticleDOI
Personality and reproductive fitness
TL;DR: Section through the fitness surface, however, show selection tends to favor high neuroticism levels in introverts and low neuroticism Levels in extroverts.