Michael C. Neale

TL;DR: While genetic factors appear to be of moderate etiologic importance in all major dimensions of mental health, the family environment is an important influence on only interpersonal relations, social support, and substance use.

TL;DR: The ABCD Study aims and design are described, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.

TL;DR: It is concluded that the administration of ATG to patients undergoing URD HCT preserves the anti-leukemia benefit of the transplant, while reducing the risk of developing GVHD, resulting in OS rates that are comparable to MRD HCT recipients.

TL;DR: In this article, bivariate genetic models were applied to data of 10,368 twins from the Netherlands Twin Register in order to estimate genetic and environmental correlations between smoking and caffeine use, and causal effects were tested using Mendelian randomization analysis in 6605 Netherlands twins and 5714 women.

TL;DR: Exome wide sequence differences and the variable alloreactive peptide binding to HLA in each DRP yields a large range of possible allore active donor T cell responses, which helps understand the apparent randomness observed in the development of alloimmune responses.