M
Mihnea Zdrenghea
Researcher at Iuliu Hațieganu University of Medicine and Pharmacy
Publications - 98
Citations - 1495
Mihnea Zdrenghea is an academic researcher from Iuliu Hațieganu University of Medicine and Pharmacy. The author has contributed to research in topics: Chronic lymphocytic leukemia & Myeloid leukemia. The author has an hindex of 15, co-authored 94 publications receiving 1044 citations. Previous affiliations of Mihnea Zdrenghea include National Institutes of Health.
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Journal ArticleDOI
COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus.
Lydia Scarfò,Thomas Chatzikonstantinou,Gian Matteo Rigolin,Giulia Quaresmini,Marina Motta,Candida Vitale,José A. García-Marco,Jose Angel Hernandez-Rivas,Fatima Miras,Mónica Baile,Juan Marquet,Carsten Utoft Niemann,Gianluigi Reda,Talha Munir,Eva Gimeno,Monia Marchetti,Francesca Maria Quaglia,Marzia Varettoni,Julio Delgado,Sunil Iyengar,Ann Janssens,Roberto Marasca,Angela Ferrari,Carolina Cuéllar-García,Gilad Itchaki,Martin Spacek,Lorenzo De Paoli,Luca Laurenti,Mark-David Levin,Enrico Lista,Francesca Romana Mauro,Martin Simkovic,Ellen van der Spek,Elisabeth Vandenberghe,Livio Trentin,Ewa Wasik-Szczepanek,Rosa Ruchlemer,Dominique Bron,Maria Rosaria De Paolis,Giovanni Del Poeta,Lucia Farina,Myriam Foglietta,Massimo Gentile,Yair Herishanu,Tobias Herold,Ozren Jakšić,Arnon P. Kater,Sabina Kersting,Lara Malerba,Lorella Orsucci,Viola Maria Popov,Paolo Sportoletti,Mohamed A. Yassin,Barbara Pocali,Gábor Barna,Annalisa Chiarenza,Gimena Dos Santos,Eugene Nikitin,Martin Andres,Maria Dimou,Michael Doubek,Alicia Enrico,Yervand K Hakobyan,Olga Kalashnikova,Macarena Ortiz Pareja,Maria Papaioannou,Davide Rossi,Nimish Shah,Amit Shrestha,Oana Stanca,Niki Stavroyianni,Vladimir Strugov,Constantine S. Tam,Mihnea Zdrenghea,Marta Coscia,Kostas Stamatopoulos,Giuseppe Rossi,Alessandro Rambaldi,Emili Montserrat,Robin Foà,Antonio Cuneo,Paolo Ghia +81 more
TL;DR: In CLL, COVID-19 severity increases with age; antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency.
Journal ArticleDOI
Vitamin D modulation of innate immune responses to respiratory viral infections.
Mihnea Zdrenghea,Heidi Makrinioti,Cristina Bagacean,Andrew Bush,Sebastian L. Johnston,Luminita A. Stanciu,Luminita A. Stanciu +6 more
TL;DR: The in vitro data on the role of vitamin D in antiviral innate immunity, the data concerning the deficient levels ofitamin D in lung diseases, and the in vivo role of supplementation as protection against respiratory viral infections in healthy individuals and in patients with chronic respiratory diseases are reviewed.
Journal ArticleDOI
Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro
Aurica G. Telcian,Mihnea Zdrenghea,Michael R. Edwards,Vasile Laza-Stanca,Patrick Mallia,Sebastian L. Johnston,Luminita A. Stanciu +6 more
TL;DR: Despite lower vitamin D receptor levels in rhinovirus‐infected epithelial cells, exogenous vitamin D increased antiviral defences most likely via cathelicidin and innate interferon pathways.
Journal ArticleDOI
Vitamin D deficiency and the COVID-19 pandemic.
Patrick Zemb,Peter Bergman,Carlos A. Camargo,Etienne Cavalier,Catherine Cormier,Marie Courbebaisse,Bruce W. Hollis,Fabrice Joulia,Salvatore Minisola,Stefan Pilz,Paweł Płudowski,François Schmitt,Mihnea Zdrenghea,Jean-Claude Souberbielle +13 more
TL;DR: In this article, the authors showed that daily vitamin D supplementation with moderate doses is safe and cheap and even a small decrease in COVID-19 infections would easily justify this intervention.
Journal ArticleDOI
The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations
Vasile Laza-Stanca,Simon D. Message,Simon D. Message,Michael R. Edwards,Hayley L. Parker,Mihnea Zdrenghea,Tatiana Kebadze,Onn Min Kon,Patrick Mallia,Patrick Mallia,Luminita A. Stanciu,Sebastian L. Johnston,Sebastian L. Johnston +12 more
TL;DR: IL-15 levels in BAL fluid were decreased in asthmatics and inversely related with airway hyperresponsiveness and with virus load during in vivo rhinovirus infection, suggesting deficient IL-15 production in asthma may be important in the pathogenesis of asthma exacerbations.