M
Martin Simkovic
Researcher at Charles University in Prague
Publications - 79
Citations - 1406
Martin Simkovic is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Medicine & Chronic lymphocytic leukemia. The author has an hindex of 11, co-authored 49 publications receiving 711 citations.
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Journal ArticleDOI
Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial
Carol Moreno,Richard Greil,Fatih Demirkan,Alessandra Tedeschi,Bertrand Anz,Loree Larratt,Martin Simkovic,Olga Samoilova,Jan Novák,Dina Ben-Yehuda,Vladimir Strugov,Devinder Gill,John G. Gribben,Emily Hsu,Chih-Jian Lih,Cathy Zhou,Fong Clow,Danelle F. James,Lori Styles,Ian W. Flinn +19 more
TL;DR: The primary endpoint was progression-free survival assessed by a masked independent review committee in the intention-to-treat population and median progression- free survival was significantly longer in the ibrutinib plus obinutuzumab group than in the chlorambucil plus ob inutuzuab group.
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ASCEND: Phase III, Randomized Trial of Acalabrutinib Versus Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia
Paolo Ghia,Andrzej Pluta,Malgorzata Wach,Daniel Lysák,Tomas Kozak,Martin Simkovic,Polina Kaplan,Iryna Kraychok,Árpád Illés,Javier de la Serna,Sean Dolan,Phillip L. Campbell,Gerardo Musuraca,Abraham Jacob,Eric J. Avery,Jae Hoon Lee,Wei Liang,Priti Patel,Cheng Quah,Wojciech Jurczak +19 more
TL;DR: Acalabrutinib significantly improved PFS compared with I-R or B-R and has an acceptable safety profile in patients with R/R CLL.
Journal ArticleDOI
COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus.
Lydia Scarfò,Thomas Chatzikonstantinou,Gian Matteo Rigolin,Giulia Quaresmini,Marina Motta,Candida Vitale,José A. García-Marco,Jose Angel Hernandez-Rivas,Fatima Miras,Mónica Baile,Juan Marquet,Carsten Utoft Niemann,Gianluigi Reda,Talha Munir,Eva Gimeno,Monia Marchetti,Francesca Maria Quaglia,Marzia Varettoni,Julio Delgado,Sunil Iyengar,Ann Janssens,Roberto Marasca,Angela Ferrari,Carolina Cuéllar-García,Gilad Itchaki,Martin Spacek,Lorenzo De Paoli,Luca Laurenti,Mark-David Levin,Enrico Lista,Francesca Romana Mauro,Martin Simkovic,Ellen van der Spek,Elisabeth Vandenberghe,Livio Trentin,Ewa Wasik-Szczepanek,Rosa Ruchlemer,Dominique Bron,Maria Rosaria De Paolis,Giovanni Del Poeta,Lucia Farina,Myriam Foglietta,Massimo Gentile,Yair Herishanu,Tobias Herold,Ozren Jakšić,Arnon P. Kater,Sabina Kersting,Lara Malerba,Lorella Orsucci,Viola Maria Popov,Paolo Sportoletti,Mohamed A. Yassin,Barbara Pocali,Gábor Barna,Annalisa Chiarenza,Gimena Dos Santos,Eugene Nikitin,Martin Andres,Maria Dimou,Michael Doubek,Alicia Enrico,Yervand K Hakobyan,Olga Kalashnikova,Macarena Ortiz Pareja,Maria Papaioannou,Davide Rossi,Nimish Shah,Amit Shrestha,Oana Stanca,Niki Stavroyianni,Vladimir Strugov,Constantine S. Tam,Mihnea Zdrenghea,Marta Coscia,Kostas Stamatopoulos,Giuseppe Rossi,Alessandro Rambaldi,Emili Montserrat,Robin Foà,Antonio Cuneo,Paolo Ghia +81 more
TL;DR: In CLL, COVID-19 severity increases with age; antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency.
Journal ArticleDOI
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.
Thomas Chatzikonstantinou,Anargyros Kapetanakis,Lydia Scarfò,Georgios Karakatsoulis,David Allsup,Alejandro Alonso Cabrero,Martin Andres,Darko Antic,Mónica Baile,Panagiotis Baliakas,Panagiotis Baliakas,Dominique Bron,Antonella Capasso,Sofia Chatzileontiadou,Raul Cordoba,Juan-Gonzalo Correa,Carolina Cuéllar-García,Lorenzo De Paoli,Maria Rosaria De Paolis,Giovanni Del Poeta,Christos Demosthenous,Maria Dimou,David Donaldson,Michael Doubek,Maria Efstathopoulou,Barbara Eichhorst,Shaimaa El-Ashwah,Alicia Enrico,Blanca Espinet,Lucia Farina,Angela Ferrari,Myriam Foglietta,Henrik Frederiksen,Moritz Fürstenau,José A. García-Marco,Rocío García-Serra,Massimo Gentile,Eva Gimeno,Andreas Glenthøj,Maria Gomes da Silva,Odit Gutwein,Yervand K Hakobyan,Yair Herishanu,Jose Angel Hernandez-Rivas,Tobias Herold,Idanna Innocenti,Gilad Itchaki,Ozren Jakšić,Ann Janssens,Оlga B Kalashnikova,Elżbieta Kalicińska,Linda Katharina Karlsson,Arnon P. Kater,Sabina Kersting,Jorge Labrador,Deepesh Lad,Luca Laurenti,Luca Laurenti,Mark-David Levin,Enrico Lista,Alberto Lopez-Garcia,Lara Malerba,Roberto Marasca,Monia Marchetti,Juan Marquet,Mattias Mattsson,Mattias Mattsson,Francesca Romana Mauro,Ivana Milosevic,Fatima Miras,Marta Morawska,Marta Morawska,Marina Motta,Talha Munir,Roberta Murru,Carsten Utoft Niemann,Raquel Nunes Rodrigues,Jacopo Olivieri,Lorella Orsucci,Maria Papaioannou,Miguel Arturo Pavlovsky,Inga Piskunova,Viola Maria Popov,Francesca Maria Quaglia,Giulia Quaresmini,Kristian Qvist,Gianluigi Reda,Gian Matteo Rigolin,Rosa Ruchlemer,Gevorg Saghumyan,Amit Shrestha,Martin Simkovic,Martin Spacek,Paolo Sportoletti,Oana Stanca,Niki Stavroyianni,Tamar Tadmor,Doreen te Raa,Sanne H. Tonino,Livio Trentin,Ellen van der Spek,Michel van Gelder,Roel van Kampen,Marzia Varettoni,Andrea Visentin,Candida Vitale,Ewa Wasik-Szczepanek,Tomasz Wróbel,Lucrecia Yáñez San Segundo,Mohamed A. Yassin,Marta Coscia,Alessandro Rambaldi,Emili Montserrat,Robin Foà,Antonio Cuneo,Kostas Stamatopoulos,Paolo Ghia +116 more
TL;DR: In this paper, the authors investigated the impact of CLL-directed treatments on the course of Coronavirus disease 2019 (COVID-19) and found that patients with chronic lymphocytic leukemia (CLL) may be more susceptible to the disease due to age, disease, and treatment-related immunosuppression.
Journal ArticleDOI
Efficacy and Safety of Zanubrutinib in Patients with Treatment-Naïve (TN) Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) with del(17p): Follow-up Results from Arm C of the SEQUOIA (BGB-3111-304) Trial
Jennifer R. Brown,Tadeusz Robak,Paolo Ghia,Brad S. Kahl,Patricia F. Walker,Wojciech Janowski,Henry Chan,Mazyar Shadman,Mazyar Shadman,Peter Ganly,Peter Ganly,L Laurenti,Stephen Opat,Monica Tani,Hanna Ciepluch,Emma Verner,Martin Simkovic,Anders Österborg,Anders Österborg,Marek Trněný,Alessandra Tedeschi,Piers Blombery,Jason C. Paik,Fangfang Yin,Shibao Feng,Vanitha Ramakrishnan,Jane Huang,Peter Hillmen,Constantine S. Tam +28 more
TL;DR: This dissertation aims to provide a history of MBBS in China and its applications in medicine and pedagogical practice over a 50-year period from 1989 to 2002.