Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy
Horia Stanescu,Mauricio Arcos-Burgos,Alan Medlar,Detlef Bockenhauer,Anna Köttgen,L. Dragomirescu,C. Voinescu,N. Patel,K. Pearce,Mike Hubank,H.A.F. Stephens,V. Laundy,Sandosh Padmanabhan,A. Zawadzka,Julia M. Hofstra,Marieke J H Coenen,M. den Heijer,Lambertus A. Kiemeney,D. Bacq-Daian,Bénédicte Stengel,S. H. Powis,Paul Brenchley,J. Feehally,Andrew J. Rees,Hanna Debiec,Jack F.M. Wetzels,Pierre Ronco,Peter W. Mathieson,Robert Kleta +28 more
TLDR
An HLA-DQA1 allele on chromosome 6p21 is most closely associated with idiopathic membranous nephropathy in persons of white ancestry and may facilitate an autoimmune response against targets such as variants of PLA2R1.Abstract:
*Drs. Stanescu and Arcos-Burgos, Mr. Medlar, and Drs. Wetzels, Ronco, Mathieson, and Kleta contributed equally to this article.read more
Citations
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Evolving importance of kidney disease: from subspecialty to global health burden
Kai-Uwe Eckardt,Josef Coresh,Olivier Devuyst,Richard J. Johnson,Anna Köttgen,Andrew S. Levey,Adeera Levin +6 more
TL;DR: Strong, graded, and consistent associations exist between clinical prognosis and two hallmarks of chronic kidney disease: reduced glomerular filtration rate and increased urinary albumin excretion.
Journal ArticleDOI
Genetically Distinct Subsets within ANCA-Associated Vasculitis
Paul A. Lyons,Tim F. Rayner,Sapna Trivedi,Julia U Holle,Richard A. Watts,David Jayne,Bo Baslund,Paul Brenchley,Annette Bruchfeld,Afzal N. Chaudhry,Jan Willem Cohen Tervaert,Panos Deloukas,Conleth Feighery,Wolfgang L. Gross,Loïc Guillevin,Iva Gunnarsson,Lorraine Harper,Zdenka Hruskova,Mark A. Little,Davide Martorana,Thomas Neumann,Sophie Ohlsson,Sophie Ohlsson,Sandosh Padmanabhan,Charles D. Pusey,Alan D. Salama,Alan D. Salama,Jan-Stephan F. Sanders,Caroline O. S. Savage,Mårten Segelmark,Mårten Segelmark,Mårten Segelmark,Coen A. Stegeman,Vladimir Tesar,Augusto Vaglio,Stefan Wieczorek,Benjamin Wilde,Jochen Zwerina,Jochen Zwerina,Andrew J. Rees,David Clayton,Kenneth G. C. Smith +41 more
TL;DR: This study confirms that the pathogenesis of ANCA-associated vasculitis has a genetic component, shows genetic distinctions between granulomatosis with polyang iitis and microscopic polyangiitis that are associated with ANCA specificity, and suggests that the response against the autoantigen proteinase 3 is a central pathogenic feature ofproteinase 3 ANCA -associated vasulitis.
Journal ArticleDOI
Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy
Nicola M. Tomas,Laurence H. Beck,Catherine Meyer-Schwesinger,Barbara Seitz-Polski,Hong Ma,Gunther Zahner,Guillaume Dolla,Elion Hoxha,Udo Helmchen,Anne-Sophie Dabert-Gay,Delphine Debayle,Michael L. Merchant,Jon B. Klein,David J. Salant,Rolf A.K. Stahl,Gérard Lambeau +15 more
TL;DR: In the authors' cohort, 15 of 154 patients with idiopathic membranous nephropathy had circulating autoantibodies to THSD7A but not to PLA2R1, a finding that suggests a distinct subgroup of patients with this condition.
Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
TL;DR: The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.
Journal ArticleDOI
KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Glomerulonephritis
Laurence H. Beck,Andrew S. Bomback,Michael J. Choi,Lawrence B. Holzman,Carol A. Langford,Laura H. Mariani,Michael J. Somers,Howard Trachtman,Meryl Waldman +8 more
TL;DR: This commentary, developed by a panel of clinical experts convened by the National Kidney Foundation, attempts to put the KDIGO guideline for glomerulonephritis into the context of the US health care system and supports the vast majority of the recommendations.
References
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