M
Min-Han Tan
Researcher at Agency for Science, Technology and Research
Publications - 186
Citations - 10277
Min-Han Tan is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Cancer & Renal cell carcinoma. The author has an hindex of 40, co-authored 173 publications receiving 8967 citations. Previous affiliations of Min-Han Tan include Singapore General Hospital & National Center for Charitable Statistics.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
External validation and comparison with other models of the International Metastatic Renal-Cell Carcinoma Database Consortium prognostic model: a population-based study
Daniel Y.C. Heng,Wanling Xie,Meredith M. Regan,Lauren C. Harshman,Georg A. Bjarnason,Ulka N. Vaishampayan,Mary J. MacKenzie,Lori Wood,Frede Donskov,Min-Han Tan,Sun Young Rha,Neeraj Agarwal,Christian Kollmannsberger,Brian I. Rini,Toni K. Choueiri +14 more
TL;DR: The Database Consortium model is now externally validated and can be applied to stratify patients by risk in clinical trials and to counsel patients about prognosis.
Journal ArticleDOI
Lifetime Cancer Risks in Individuals with Germline PTEN Mutations
TL;DR: Lifetime risks for a variety of cancers, now extending to colorectal cancer, kidney cancer, and melanoma, are increased in patients with PTEN mutations, and a comprehensive approach is proposed to surveillance of patients withPTEN mutations.
Journal ArticleDOI
An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
Aikseng Ooi,Jing Chii Wong,David Petillo,Douglas Roossien,Victoria Perrier-Trudova,Victoria Perrier-Trudova,Douglas Whitten,Bernice Wong Hui Min,Min-Han Tan,Zhongfa Zhang,Ximing J. Yang,Ming Zhou,Betty Gardie,Vincent Molinié,Stéphane Richard,Puay Hoon Tan,Bin Tean Teh,Kyle A. Furge +17 more
TL;DR: It is identified that fumarate can directly up-regulate antioxidant response element (ARE)-controlled genes and is up-regulated upon FH knockdown as well as in FH null cell lines, and AKR1B10 overexpression is also a prominent feature in both hereditary and sporadic PRCC2.
Journal ArticleDOI
A Clinical Scoring System for Selection of Patients for PTEN Mutation Testing Is Proposed on the Basis of a Prospective Study of 3042 Probands
Min-Han Tan,Jessica Mester,Jessica Mester,Charissa Peterson,Charissa Peterson,Yi-Ran Yang,Yi-Ran Yang,Jin Lian Chen,Jin Lian Chen,Lisa Rybicki,Lisa Rybicki,Kresimira Milas,Holly J. Pederson,Berna K. Remzi,Mohammed S. Orloff,Mohammed S. Orloff,Charis Eng +16 more
TL;DR: The first evidence-based clinical practice model to select patients for genetics referral and PTEN mutation testing is presented, further supported biologically by protein correlation.