D
Dave Clary
Researcher at University of California, Davis
Publications - 16
Citations - 1226
Dave Clary is an academic researcher from University of California, Davis. The author has contributed to research in topics: Medicine & Candidate gene. The author has an hindex of 5, co-authored 12 publications receiving 875 citations. Previous affiliations of Dave Clary include Veterinary Medical Teaching Hospital & Centre national de la recherche scientifique.
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Journal ArticleDOI
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson,Ann M. Flenniken,Xiao Ji,Lydia Teboul,Michael D. Wong,Jacqueline K. White,Terrence F. Meehan,Wolfgang Weninger,Henrik Westerberg,Hibret A. Adissu,Candice N. Baker,Lynette Bower,James M. Brown,L. Brianna Caddle,Francesco Chiani,Dave Clary,James Cleak,Mark J. Daly,James M. Denegre,Brendan Doe,Mary E. Dolan,Sarah M. Edie,Helmut Fuchs,Valerie Gailus-Durner,Antonella Galli,Alessia Gambadoro,Juan Gallegos,Shiying Guo,Neil R. Horner,Chih-Wei Hsu,Sara Johnson,Sowmya Kalaga,Lance C. Keith,Louise Lanoue,Thomas N. Lawson,Monkol Lek,Monkol Lek,Manuel Mark,Susan Marschall,Jeremy Mason,Melissa L. McElwee,Susan Newbigging,Lauryl M. J. Nutter,Kevin A. Peterson,Ramiro Ramirez-Solis,Douglas J. Rowland,Edward Ryder,Kaitlin E. Samocha,Kaitlin E. Samocha,John R. Seavitt,Mohammed Selloum,Zsombor Szoke-Kovacs,Masaru Tamura,Amanda G. Trainor,Ilinca Tudose,Shigeharu Wakana,Jonathan Warren,Olivia Wendling,David B. West,Leeyean Wong,Atsushi Yoshiki,Daniel G. MacArthur,Daniel G. MacArthur,Glauco P. Tocchini-Valentini,Xiang Gao,Paul Flicek,Allan Bradley,William C. Skarnes,Monica J. Justice,Helen Parkinson,Mark W. Moore,Sara Wells,Robert E. Braun,Karen L. Svenson,Martin Hrabé de Angelis,Yann Herault,Timothy J. Mohun,Ann-Marie Mallon,R. Mark Henkelman,Steve D.M. Brown,David J. Adams,Kevin C K Lloyd,Colin McKerlie,Arthur L. Beaudet,Maja Bucan,Stephen A. Murray +85 more
TL;DR: It is shown that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts and reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background.
Journal ArticleDOI
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Michael R. Bowl,Michelle Simon,Neil J. Ingham,Neil J. Ingham,Simon Greenaway,Luis Santos,Heather Cater,Sarah Taylor,Jeremy Mason,Natalja Kurbatova,Selina Pearson,Lynette Bower,Dave Clary,Hamid Meziane,Patrick T. Reilly,Osamu Minowa,Lois Kelsey,Lois Kelsey,Glauco P. Tocchini-Valentini,Xiang Gao,Allan Bradley,William C. Skarnes,Mark W. Moore,Arthur L. Beaudet,Monica J. Justice,John R. Seavitt,Mary E. Dickinson,Wolfgang Wurst,Martin Hrabé de Angelis,Yann Herault,Shigeharu Wakana,Lauryl M. J. Nutter,Lauryl M. J. Nutter,Ann M. Flenniken,Ann M. Flenniken,Colin McKerlie,Colin McKerlie,Stephen A. Murray,Karen L. Svenson,Robert E. Braun,David B. West,Kevin C K Lloyd,David J. Adams,Jacqui White,Natasha A. Karp,Paul Flicek,Damian Smedley,Terrence F. Meehan,Helen Parkinson,Lydia Teboul,Sara Wells,Karen P. Steel,Karen P. Steel,Ann-Marie Mallon,Steve D.M. Brown +54 more
TL;DR: A hearing loss screen in a cohort of 3006 mouse knockout strains reveals a large and unexplored genetic landscape involved with auditory function and identifies 52 new candidate genes for genetic hearing loss.
Journal ArticleDOI
Functional integration of non-native carotenoids into chloroplasts by viral-derived expression of capsanthin-capsorubin synthase in Nicotiana benthamiana
TL;DR: It is demonstrated that higher plant antenna complexes can accommodate non-native carotenoids and provide compelling evidence for functional remodelling of photosynthetic membranes toward a better photoreactivity by rational design of the incorporatedCarotenoid structures.
Journal ArticleDOI
Identification of genes required for eye development by high-throughput screening of mouse knockouts.
Bret A. Moore,Brian C. Leonard,Lionel Sebbag,Sydney G. Edwards,Ann E. Cooper,Denise M. Imai,Ewan Straiton,Luis Santos,Christopher M. Reilly,Stephen M Griffey,Lynette Bower,Dave Clary,Jeremy Mason,Michel Roux,Hamid Meziane,Yann Herault,Colin McKerlie,Ann M Flenniken,Lauryl M. J. Nutter,Zorana Berberovic,Celeste Owen,Susan Newbigging,Hibret A. Adissu,Mohammed Eskandarian,Chih-Wei Hsu,Sowmya Kalaga,Uchechukwu Udensi,Chinwe Asomugha,Ritu Bohat,Juan Gallegos,John R. Seavitt,Jason D. Heaney,Arthur L. Beaudet,Mary E. Dickinson,Monica J. Justice,Monica J. Justice,Vivek M. Philip,Vivek Kumar,Karen L. Svenson,Robert Braun,Sara Wells,Heather Cater,Michelle Stewart,Sharon Clementson-Mobbs,Russell Joynson,Xiang Gao,Tomohiro Suzuki,Shigeharu Wakana,Damian Smedley,Je Kyung Seong,Glauco P. Tocchini-Valentini,Mark W. Moore,Colin Fletcher,Natasha A. Karp,Ramiro Ramirez-Solis,Jacqueline K. White,Martin Hrabé de Angelis,Wolfgang Wurst,Sara M Thomasy,Paul Flicek,Helen Parkinson,Steve D.M. Brown,Terrence F. Meehan,Patsy M Nishina,Stephen A. Murray,Mark P Krebs,Ann-Marie Mallon,Kevin C K Lloyd,Christopher J. Murphy,Ala Moshiri +69 more
TL;DR: The identification of 347 mouse genes that influence ocular phenotypes when knocked out greatly increases the current number of genes known to contribute to ocular disease, and it is likely that many of the genes will subsequently prove to be important in human ocular development and disease.
Journal ArticleDOI
A Population Study of Common Ocular Abnormalities in C57BL/6N Rd8 Mice
Bret A. Moore,Michel Roux,Lionel Sebbag,Ann E. Cooper,Sydney G. Edwards,Brian C. Leonard,Denise M. Imai,Stephen M Griffey,Lynette Bower,Dave Clary,Kevin C K Lloyd,Yann Herault,Sara M Thomasy,Christopher J. Murphy,Ala Moshiri +14 more
TL;DR: Ocular abnormalities are common in anterior and posterior segments of the C57BL/6N mouse, the most common background on which single-gene knockout mice have been made.