Karen L. Svenson

TL;DR: The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way the authors approach human health and disease.

TL;DR: It is shown that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts and reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background.

TL;DR: Repeated dietary shifts demonstrated that most changes to the gut microbiota are reversible, while also uncovering bacteria whose abundance depends on prior consumption, emphasizing the dominant role that diet plays in shaping interindividual variations in host-associated microbial communities.

TL;DR: The Collaborative Cross Consortium reports here on the development of a unique genetic resource population, a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains, which shows that founder haplotypes are inherited at the expected frequency.

TL;DR: Analytical methods for genetic mapping using the JAX Diversity Outbred population are described and the power and high mapping resolution achieved with this population are demonstrated by mapping a serum cholesterol trait to a 2-Mb region on chromosome 3 containing only 11 genes.