L
Lynette Bower
Researcher at University of California, Davis
Publications - 18
Citations - 3346
Lynette Bower is an academic researcher from University of California, Davis. The author has contributed to research in topics: Gene & Candidate gene. The author has an hindex of 9, co-authored 15 publications receiving 2847 citations. Previous affiliations of Lynette Bower include University of California, Berkeley.
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The Universal Protein Resource (UniProt) in 2010
Rolf Apweiler,Maria Jesus Martin,Claire O'Donovan,Michele Magrane,Yasmin Alam-Faruque,Ricardo Antunes,Daniel Barrell,Benoit Bely,M Bingley,David Binns,Lynette Bower,Paul Browne,WM Chan,E. Dimmer,Ruth Y. Eberhardt,A. Fedotov,Rebecca E. Foulger,John S. Garavelli,Rachael P. Huntley,Julius O.B. Jacobsen,M. Kleen,Kati Laiho,Rasko Leinonen,Duncan Legge,Quan Lin,W Liu,Jie Luo,Sandra Orchard,Samuel Patient,Diego Poggioli,Manuela Pruess,Matthew Corbett,G di Martino,M Donnelly,P van Rensburg,Amos Marc Bairoch,Lydie Bougueleret,Ioannis Xenarios,S Altairac,Andrea H. Auchincloss,Ghislaine Argoud-Puy,Kristian B. Axelsen,Delphine Baratin,M. C. Blatter,Brigitte Boeckmann,Jerven Bolleman,L. Bollondi,Emmanuel Boutet,SB Quintaje,Lionel Breuza,Alan Bridge,E. Decastro,L Ciapina,D Coral,Elisabeth Coudert,Isabelle Cusin,G Delbard,M Doche,Dolnide Dornevil,Paula Duek Roggli,Séverine Duvaud,Anne Estreicher,L Famiglietti,M Feuermann,Sebastien Gehant,N. Farriol-Mathis,Serenella Ferro,Elisabeth Gasteiger,Alain Gateau,Gerritsen,Arnaud Gos,Nadine Gruaz-Gumowski,Ursula Hinz,Chantal Hulo,Nicolas Hulo,J. James,S. Jimenez,Florence Jungo,T. Kappler,Guillaume Keller,Corinne Lachaize,L Lane-Guermonprez,Petra S. Langendijk-Genevaux,Lara,P Lemercier,Damien Lieberherr,Tdo Lima,Mangold,Xavier D. Martin,Patrick Masson,M. Moinat,Anne Morgat,Anaïs Mottaz,Salvo Paesano,Ivo Pedruzzi,Sandrine Pilbout,Pillet,Sylvain Poux,Monica Pozzato,Nicole Redaschi,Catherine Rivoire,Bernd Roechert,Maria Victoria Schneider,Christian J. A. Sigrist,K Sonesson,S Staehli,Eleanor J Stanley,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Laure Verbregue,A-L Veuthey,L Yip,L Zuletta,Cathy H. Wu,Cecilia N. Arighi,Leslie Arminski,Winona C. Barker,Chuming Chen,Yingfei Chen,Z-Z Hu,Hongzhan Huang,Raja Mazumder,Peter B. McGarvey,Darren A. Natale,Jules Nchoutmboube,Natalia V. Petrova,N Subramanian,Baris E. Suzek,U. Ugochukwu,Sona Vasudevan,C. R. Vinayaka,LS Yeh,Jian Zhang +133 more
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High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson,Ann M. Flenniken,Xiao Ji,Lydia Teboul,Michael D. Wong,Jacqueline K. White,Terrence F. Meehan,Wolfgang Weninger,Henrik Westerberg,Hibret A. Adissu,Candice N. Baker,Lynette Bower,James M. Brown,L. Brianna Caddle,Francesco Chiani,Dave Clary,James Cleak,Mark J. Daly,James M. Denegre,Brendan Doe,Mary E. Dolan,Sarah M. Edie,Helmut Fuchs,Valerie Gailus-Durner,Antonella Galli,Alessia Gambadoro,Juan Gallegos,Shiying Guo,Neil R. Horner,Chih-Wei Hsu,Sara Johnson,Sowmya Kalaga,Lance C. Keith,Louise Lanoue,Thomas N. Lawson,Monkol Lek,Monkol Lek,Manuel Mark,Susan Marschall,Jeremy Mason,Melissa L. McElwee,Susan Newbigging,Lauryl M. J. Nutter,Kevin A. Peterson,Ramiro Ramirez-Solis,Douglas J. Rowland,Edward Ryder,Kaitlin E. Samocha,Kaitlin E. Samocha,John R. Seavitt,Mohammed Selloum,Zsombor Szoke-Kovacs,Masaru Tamura,Amanda G. Trainor,Ilinca Tudose,Shigeharu Wakana,Jonathan Warren,Olivia Wendling,David B. West,Leeyean Wong,Atsushi Yoshiki,Daniel G. MacArthur,Daniel G. MacArthur,Glauco P. Tocchini-Valentini,Xiang Gao,Paul Flicek,Allan Bradley,William C. Skarnes,Monica J. Justice,Helen Parkinson,Mark W. Moore,Sara Wells,Robert E. Braun,Karen L. Svenson,Martin Hrabé de Angelis,Yann Herault,Timothy J. Mohun,Ann-Marie Mallon,R. Mark Henkelman,Steve D.M. Brown,David J. Adams,Kevin C K Lloyd,Colin McKerlie,Arthur L. Beaudet,Maja Bucan,Stephen A. Murray +85 more
TL;DR: It is shown that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts and reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background.
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Ongoing and future developments at the Universal Protein Resource
Anne Morgat,Rolf Apweiler,Maria Jesus Martin,Claire O'Donovan,Michele Magrane,Yasmin Alam-Faruque,Ricardo Antunes,Daniel Barrell,Benoit Bely,M Bingley,David Binns,Lynette Bower,Paul Browne,Chan Wm,E. Dimmer,Ruth Y. Eberhardt,F. Fazzini,A. Fedotov,Rebecca E. Foulger,John S. Garavelli,Castro Lg,Rachael P. Huntley,Julius O.B. Jacobsen,M. Kleen,Kati Laiho,Duncan Legge,Quan Lin,W Liu,Jie Luo,Sandra Orchard,S. Patient,Klemens Pichler,Diego Poggioli,Nikolas Pontikos,Manuela Pruess,Steven Rosanoff,Tony Sawford,H. Sehra,Edward Turner,M. Corbett,M Donnelly,Van Rensburg P,Ioannis Xenarios,Lydie Bougueleret,Andrea H. Auchincloss,Ghislaine Argoud-Puy,Kristian B. Axelsen,Amos Marc Bairoch,Delphine Baratin,Blatter Mc,Brigitte Boeckmann,Jerven Bolleman,L. Bollondi,Emmanuel Boutet,Quintaje Sb,Lionel Breuza,Alan Bridge,E. Decastro,Elisabeth Coudert,Isabelle Cusin,M Doche,Dolnide Dornevil,Séverine Duvaud,Anne Estreicher,L Famiglietti,M Feuermann,Sebastien Gehant,Serenella Ferro,Elisabeth Gasteiger,Alain Gateau,Vivienne Baillie Gerritsen,Arnaud Gos,Nadine Gruaz-Gumowski,Ursula Hinz,Chantal Hulo,Nicolas Hulo,J. James,S. Jimenez,Florence Jungo,T. Kappler,Guillaume Keller,Vicente Lara,P Lemercier,Damien Lieberherr,Xavier D. Martin,Patrick Masson,M. Moinat,Salvo Paesano,Ivo Pedruzzi,Sandrine Pilbout,Sylvain Poux,Monica Pozzato,Nicole Redaschi,Catherine Rivoire,Bernd Roechert,Maria Victoria Schneider,Christian J. A. Sigrist,K Sonesson,S Staehli,E. Stanley,Andre Stutz,Shyamala Sundaram,Michael Tognolli,Laure Verbregue,Veuthey Al,Wu Ch,Arighi Cn,Leslie Arminski,Barker Wc,Chuming Chen,Yongxing Chen,P. Dubey,He Huang,Raja Mazumder,Peter B. McGarvey,Natale Da,Natarajan Tg,J. Nchoutmboube,Roberts Nv,Suzek Be,U. Ugochukwu,Vinayaka Cr,Qiang Wang,Yuqi Wang,Yeh Ls,Jian Zhang +125 more
TL;DR: The primary mission of Universal Protein Resource (UniProt) is to support biological research by maintaining a stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and querying interfaces freely accessible to the scientific community.
Journal ArticleDOI
Prevalence of sexual dimorphism in mammalian phenotypic traits
Natasha A. Karp,Natasha A. Karp,Jeremy Mason,Arthur L. Beaudet,Yoav Benjamini,Lynette Bower,Robert E. Braun,Steve D.M. Brown,Elissa J. Chesler,Mary E. Dickinson,Ann M. Flenniken,Helmut Fuchs,Martin Hrabé de Angelis,Xiang Gao,Shiying Guo,Simon Greenaway,Ruth Heller,Yann Herault,Monica J. Justice,Natalja Kurbatova,Christopher J. Lelliott,Kevin C K Lloyd,Ann-Marie Mallon,Judith E. Mank,Hiroshi Masuya,Colin McKerlie,Terrence F. Meehan,Richard Mott,Stephen A. Murray,Helen Parkinson,Ramiro Ramirez-Solis,Luis Santos,John R. Seavitt,Damian Smedley,Tania Sorg,Anneliese O. Speak,Karen P. Steel,Karen P. Steel,Karen L. Svenson,Shigeharu Wakana,David B. West,Sara Wells,Henrik Westerberg,Shay Yaacoby,Jacqueline K. White +44 more
TL;DR: A large proportion of mammalian traits both in wildtype and mutants are influenced by sex, and this result has implications for interpreting disease phenotypes in animal models and humans.
Journal ArticleDOI
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
Terrence F. Meehan,Nathalie Conte,David B. West,Julius O.B. Jacobsen,Jeremy Mason,Jonathan Warren,Chao-Kung Chen,Ilinca Tudose,Mike Relac,Peter Matthews,Natasha A. Karp,Luis Santos,Tanja Fiegel,Natalie Ring,Henrik Westerberg,Simon Greenaway,Duncan Sneddon,Hugh P. Morgan,Gemma F. Codner,Michelle Stewart,James M. Brown,Neil R. Horner,Melissa A. Haendel,Nicole L. Washington,Christopher J. Mungall,Corey L. Reynolds,Juan Gallegos,Valerie Gailus-Durner,Tania Sorg,Guillaume Pavlovic,Lynette Bower,Mark W. Moore,Iva Morse,Xiang Gao,Glauco P. Tocchini-Valentini,Yuichi Obata,Soo Young Cho,Je Kyung Seong,John R. Seavitt,Arthur L. Beaudet,Mary E. Dickinson,Yann Herault,Wolfgang Wurst,Martin Hrabé de Angelis,Kevin C K Lloyd,Ann M. Flenniken,Lauryl M. J. Nutter,Susan Newbigging,Colin McKerlie,Monica J. Justice,Stephen A. Murray,Karen L. Svenson,Robert E. Braun,Jacqueline K. White,Allan Bradley,Paul Flicek,Sara Wells,William C. Skarnes,David J. Adams,Helen Parkinson,Ann-Marie Mallon,Stephen D.M. Brown,Damian Smedley +62 more
TL;DR: Analyzing the first 3,328 genes identified models for 360 diseases, including the first models, to the knowledge, for type C Bernard–Soulier, Bardet–Biedl-5 and Gordon Holmes syndromes, and 90% of phenotype annotations were novel, providing functional evidence for 1,092 genes and candidates in genetically uncharacterized diseases.