Morgan E. Freret

TL;DR: The identification of a previously undescribed population of immunophenotypic neural precursor cells in the human and murine brainstem whose temporal and spatial distributions correlate closely with the incidence of DIPG are reported and suggest that the Hh pathway represents a potential therapeutic target in this devastating pediatric tumor.

TL;DR: Using electrophysiology, subtype-specific neuron silencing, and conditional gene knockout, it is shown that these molecularly defined 5HT neuron subtypes are functionally distinct.

TL;DR: Subventricular tumor spread is shown in the majority of patients, typically later in the course of their disease, as future therapies evolve to control local disease, strategies including extended or whole brain irradiation may become crucial as therapies improve and patients survive longer in the natural history of their cancer.

TL;DR: In the brainstem median raphe (MR) neurons expressing the serotonergic regulator gene PET1 send collateralized projections to forebrain regions to modulate affective, memory-related, and circadian behaviors.