M
Morna J. Dorsey
Researcher at University of California, San Francisco
Publications - 61
Citations - 2402
Morna J. Dorsey is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Severe combined immunodeficiency. The author has an hindex of 19, co-authored 50 publications receiving 1689 citations. Previous affiliations of Morna J. Dorsey include French Institute of Health and Medical Research & University of South Florida.
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Journal ArticleDOI
AR101 Oral Immunotherapy for Peanut Allergy
Brian P. Vickery,Andrea Vereda,Thomas B. Casale,Kirsten Beyer,George Du Toit,Jonathan O'b Hourihane,Stacie M. Jones,Stacie M. Jones,Wayne G. Shreffler,Annette Marcantonio,Rezi Zawadzki,Lawrence Sher,W. Carr,Stanley Fineman,Leon Greos,Rima Rachid,M Dolores Ibáñez,Stephen A. Tilles,Amal Assa'ad,Caroline Nilsson,Ned Rupp,Michael J Welch,Gordon Sussman,Sharon Chinthrajah,Katharina Blumchen,Ellen Sher,Jonathan M. Spergel,Frederick E Leickly,Stefan Zielen,Julie Wang,Georgiana M Sanders,Robert A. Wood,Amarjit Cheema,Carsten Bindslev-Jensen,Stephanie A. Leonard,Rita Kachru,Douglas T Johnston,Frank C Hampel,Edwin H. Kim,Aikaterini Anagnostou,Jacqueline A. Pongracic,Moshe Ben-Shoshan,Hemant P Sharma,Allan Stillerman,Hugh H Windom,William H. Yang,Antonella Muraro,José Manuel Zubeldia,Vibha Sharma,Morna J. Dorsey,Hey Chong,Jason A. Ohayon,J. Andrew Bird,Tara F. Carr,Dareen Siri,Montserrat Fernandez-Rivas,David K Jeong,David Fleischer,Jay A. Lieberman,Anthony E.J. Dubois,Marina Tsoumani,Christina E. Ciaccio,Jay M. Portnoy,Lyndon E Mansfield,Stephen B Fritz,Bruce J. Lanser,Jonathan Matz,Hanneke N G Oude Elberink,Pooja Varshney,Stephen G Dilly,Daniel C. Adelman,A. Wesley Burks +71 more
TL;DR: Treatment with AR101 resulted in higher doses of peanut protein that could be ingested without dose‐limiting symptoms and in lower symptom severity during peanut exposure at the exit food challenge than placebo, in this phase 3 trial of oral immunotherapy in children and adolescents who were highly allergic to peanut.
Journal ArticleDOI
Update on the use of immunoglobulin in human disease: A review of evidence
Elena E. Perez,Jordan S. Orange,Francisco A. Bonilla,Javier Chinen,Ivan K. Chinn,Morna J. Dorsey,Yehia El-Gamal,Terry Harville,Elham Hossny,Bruce Mazer,Robert P. Nelson,Elizabeth Secord,Stanley C. Jordan,E. Richard Stiehm,Ashley Vo,Mark Ballow +15 more
TL;DR: This work provides an update of the evidence‐based guideline on immunoglobulin therapy, last published in 2006, and suggests that careful consideration of its indications and administration is warranted.
Journal ArticleDOI
Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.
Gulbu Uzel,Elizabeth P. Sampaio,Monica G. Lawrence,Amy P. Hsu,Mary J. Hackett,Morna J. Dorsey,Richard J. Noel,James W. Verbsky,Alexandra F. Freeman,Erin Janssen,Francisco A. Bonilla,Joseph Pechacek,Prabha Chandrasekaran,Sarah K. Browne,Anahita Agharahimi,Anahita Agharahimi,Ahmed M. Gharib,Sara Ciullini Mannurita,Jae-Joon Yim,Eleonora Gambineri,Troy R. Torgerson,Dat Q. Tran,Joshua D. Milner,Steven M. Holland +23 more
TL;DR: In this paper, the role of gain-of-function mutations in signal transducer and activator of transcription (STAT) 1 cause a broad spectrum of disease, ranging from severe viral and bacterial infections (amorphic alleles) to mild disseminated mycobacterial disease (hypomorphic alleles), to chronic mucocutaneous candidiasis (CMC; hypermorphic allele).
Journal ArticleDOI
Lentiviral gene therapy for X-linked chronic granulomatous disease.
Donald B. Kohn,Claire Booth,Elizabeth M. Kang,Sung-Yun Pai,Kit L. Shaw,Giorgia Santilli,Myriam Armant,Karen F. Buckland,Uimook Choi,Suk See De Ravin,Morna J. Dorsey,Caroline Y. Kuo,Diego Leon-Rico,Christine Rivat,Natalia Izotova,Kimberly Gilmour,Katie Snell,Jinhua Xu-Bayford Dip,Jinan Darwish,Emma C. Morris,Dayna Terrazas,Leo D. Wang,Leo D. Wang,Christopher A. Bauser,Tobias Paprotka,Douglas B. Kuhns,John R. Gregg,Hayley Raymond,John K. Everett,Geraldine Honnet,Luca Biasco,Peter E. Newburger,Frederic D. Bushman,Manuel Grez,H. Bobby Gaspar,David A. Williams,Harry L. Malech,Anne Galy,Adrian J. Thrasher +38 more
TL;DR: Nine severely affected X-linked CGD patients who received ex vivo autologous CD34 + hematopoietic stem and progenitor cell-based lentiviral gene therapy following myeloablative conditioning received early evidence supporting its safety and efficacy in treating patients with X- linked chronic granulomatous disease.
Journal ArticleDOI
Newborn Screening for Severe Combined Immunodeficiency and T-cell Lymphopenia in California, 2010-2017.
George S. Amatuni,George S. Amatuni,Robert J. Currier,Joseph A. Church,Tracey Bishop,Elena Grimbacher,Alan A. Nguyen,Rajni Agarwal-Hashmi,Constantino P. Aznar,Manish J. Butte,Morton J. Cowan,Morna J. Dorsey,Christopher C. Dvorak,Neena Kapoor,Donald B. Kohn,M. Louise Markert,Theodore B. Moore,Stanley J. Naides,Stanley Sciortino,Lisa Feuchtbaum,Rasoul Alikhani Koupaei,Jennifer M. Puck +21 more
TL;DR: Population-based TREC testing, although unable to detect immune defects in which T cells are present at birth, is effective for identifying SCID and clinically important TCL with high sensitivity and specificity and supports the rapid, widespread adoption of SCID newborn screening.