N
Nan Lin
Researcher at Harvard University
Publications - 1220
Citations - 65601
Nan Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Breast cancer. The author has an hindex of 105, co-authored 687 publications receiving 54545 citations. Previous affiliations of Nan Lin include University of Michigan & Fujian Medical University.
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Whole exome sequencing (WES) in hormone-receptor positive (HR+) metastatic breast cancer (MBC) to identify mediators of resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i).
Seth A. Wander,Ofir Cohen,Gabriela N. Johnson,Dewey Kim,Flora Luo,Pingping Mao,Utthara Nayar,Karla Helvie,Lori Marini,Samuel S. Freeman,Gad Getz,Levi A. Garraway,Eric P. Winer,Nan Lin,Nikhil Wagle +14 more
TL;DR: Combining CDK4/6i with endocrine therapy results in prolongation of disease control in HR+ MBC, though resistance invariably occurs.
Journal ArticleDOI
Tumor subtypes and survival in male breast cancer
Julieta Leone,Rachel A. Freedman,Nan Lin,Sara M. Tolaney,Carlos Teodoro Vallejo,Bernardo Amadeo Leone,Eric P. Winer,Jose Pablo Leone +7 more
TL;DR: In this article, the authors examined tumor subtypes by patient characteristics and performed multivariate Cox proportional hazards analyses to determine the associations of each variable with overall survival and breast cancer-specific survival.
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Determination of the maximum tolerated dose (MTD) of the CNS penetrant tyrosine kinase inhibitor (TKI) tesevatinib administered in combination with trastuzumab in HER2+ patients with metastatic breast cancer (BC).
Nan Lin,Rachel A. Freedman,Kathy D. Miller,Komal Jhaveri,David Eiznhamer,Mark S. Berger,Erika Hamilton +6 more
TL;DR: Tesevatinib is a potent EGFR in patients with brain metastases diagnosed with HER2+ BC and there is a need for a potent TKI that crosses the BBB and penetrates CNS tissues.
Journal ArticleDOI
Ingestion bioaccessibility of indoor dust-bound PAHs: Inclusion of a sorption sink to simulate passive transfer across the small intestine
Peng Gao,Dantong Liu,Li Guo,Chuan He,Nan Lin,Yanfeng Xing,Changhao Yao,Bing Wu,Zelin Zheng,Yue Wang,Jian Hang +10 more
TL;DR: The results indicated that the passive transfer fraction of PAH12 is large and needs to be considered in exposure and risk assessments.